| Behavioral counseling and varenicline treatment for smoking cessation. | |
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MedLine Citation:
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PMID: 20409497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Smoking remains the primary preventable cause of death and illness in the U.S. Effective, convenient treatment programs are needed to reduce smoking prevalence. PURPOSE: This study compared the effectiveness of three modalities of a behavioral smoking-cessation program in smokers using varenicline. METHODS: Current treatment-seeking smokers (n=1202) were recruited from a large healthcare organization between October 2006 and October 2007. Eligible participants were randomized to one of three smoking-cessation interventions: web-based counseling (n=401); proactive telephone-based counseling (PTC; n=402); or combined PTC and web counseling (n=399). All participants received a standard 12-week FDA-approved course of varenicline. Self-report determined the primary outcomes (7-day point prevalent abstinence at 3- and 6-month follow-ups); the number of days varenicline was taken; and treatment-related symptoms. Behavioral measures determined utilization of both the web- and Phone-based counseling. RESULTS: Intent-to-treat analyses revealed relatively high percentages of abstinence at 3 months (38.9%, 48.5%, 43.4%) and at 6 months (30.7%, 34.3%, 33.8%) for the web, PTC, and PTC-web groups, respectively. The PTC group had a significantly higher percentage of abstinence than the web group at 3 months (OR=1.48, 95% CI=1.12, 1.96), but no between-group differences in abstinence outcomes were seen at 6 months. CONCLUSIONS: Phone counseling had greater treatment advantage for early cessation and appeared to increase medication adherence, but the absence of differences at 6 months suggests that any of the interventions hold promise when used in conjunction with varenicline. |
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Authors:
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Gary E Swan; Jennifer B McClure; Lisa M Jack; Susan M Zbikowski; Harold S Javitz; Sheryl L Catz; Mona Deprey; Julie Richards; Timothy A McAfee |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of preventive medicine Volume: 38 ISSN: 1873-2607 ISO Abbreviation: Am J Prev Med Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-07-29 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8704773 Medline TA: Am J Prev Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 482-90 Citation Subset: IM |
Copyright Information:
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2010 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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SRI International, Menlo Park, California 94025, USA. gary.swan@sri.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Benzazepines / therapeutic use* Counseling / methods* Female Humans Internet Male Middle Aged Nicotinic Agonists / therapeutic use* Outcome Assessment (Health Care) Quinoxalines / therapeutic use* Smoking Cessation / methods* Telephone Washington |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA071358-09/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 0/Nicotinic Agonists; 0/Quinoxalines; 0/varenicline |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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