Document Detail


Behavioral consequences of intracerebral vasopressin and oxytocin: focus on learning and memory.
MedLine Citation:
PMID:  8880728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since the pioneering work of David de Wied and his colleagues, the neuropeptides arginine vasopressin and oxytocin have been thought to play a pivotal role in behavioral regulation in general, and in learning and memory in particular. The present review focuses on the behavioral effects of intracerebral arginine vasopressin and oxytocin, with particular emphasis on the role of these neuropeptides as signals in interneuronal communication. We also discuss several methodological approaches that have been used to reveal the importance of these intracerebral neuropeptides as signals within signaling cascades. The literature suggests that arginine vasopressin improves, and oxytocin impairs, learning and memory. However, a critical analysis of the subject indicates the necessity for a revision of this generalized concept. We suggest that, depending on the behavioral test and the brain area under study, these endogenous neuropeptides are differentially involved in behavioral regulation; thus, generalizations derived from a single behavioral task should be avoided. In particular, recent studies on rodents indicate that socially relevant behaviors triggered by olfactory stimuli and paradigms in which the animals have to cope with an intense stressor (e.g., foot-shock motivated active or passive avoidance) are controlled by both arginine vasopressin and oxytocin released intracerebrally.
Authors:
M Engelmann; C T Wotjak; I Neumann; M Ludwig; R Landgraf
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  20     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  1996  
Date Detail:
Created Date:  1997-02-05     Completed Date:  1997-02-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  341-58     Citation Subset:  IM    
Affiliation:
Department of Neuroendocrinology, Clinical Institute, Max Planck Institute of Psychiatry, Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / physiology*
Learning / physiology*
Memory / physiology*
Oxytocin / physiology*
Vasopressins / physiology*
Chemical
Reg. No./Substance:
11000-17-2/Vasopressins; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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