| Behavioral characteristics, associative learning capabilities, and dynamic association mapping in an animal model of cerebellar degeneration. | |
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MedLine Citation:
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PMID: 20410355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Young adult heterozygous Lurcher mice constitute an excellent model for studying the role of the cerebellar cortex in motor performance-including the acquisition of new motor abilities-because of the early postnatal degeneration of almost all of their Purkinje and granular cells. Wild-type and Lurcher mice were classically conditioned for eyelid responses using a delay paradigm with or without an electrolytic lesion in the interpositus nucleus. Although the late component of electrically evoked blink reflexes was smaller in amplitude and had a longer latency in Lurcher mice than that in controls, the two groups of animals presented similar acquisition curves for eyeblink conditioning. The lesion of the interpositus nucleus affected both groups of animals equally for the generation of reflex and conditioned eyelid responses. Furthermore, we recorded the multiunitary activity at the red and interpositus nuclei during the same type of associative learning. In both nuclei, the neural firing activity lagged the beginning of the conditioned response (determined by orbicularis oculi muscle response). Although red nucleus neurons and muscle activities presented a clear functional coupling (strong correlation and low asymmetry) across conditioning, the coupling between interpositus neurons and either red nucleus neurons or muscle activities was slightly significant (weak correlation and high asymmetry). Lurcher mice presented a nonlinear coupling (high asymmetry) between red nucleus neurons and muscle activities, with an evident compensatory adjustment in the correlation of firing between interpositus and red nuclei neurons (a coupling with low asymmetry), aimed probably at compensating the absence of cerebellar cortical neurons. |
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Authors:
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Elena Porras-García; Raudel Sánchez-Campusano; David Martínez-Vargas; Eduardo Domínguez-del-Toro; Jan Cendelín; Frantisek Vozeh; José M Delgado-García |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-21 |
Journal Detail:
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Title: Journal of neurophysiology Volume: 104 ISSN: 1522-1598 ISO Abbreviation: J. Neurophysiol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 346-65 Citation Subset: IM |
Affiliation:
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Division of Anatomy and Human Embryology, Pablo de Olavide University, Seville, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Association Learning / physiology* Behavior, Animal / physiology* Blinking / physiology Brain Mapping Cerebellum / pathology* Conditioning, Eyelid / physiology Efferent Pathways / cytology, physiology Electromyography Electrophysiological Phenomena Immunohistochemistry Mice Mice, Neurologic Mutants Nonlinear Dynamics Oculomotor Muscles / physiology Red Nucleus / physiology Spinocerebellar Degenerations / pathology, psychology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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