| Behavioral and cardiac responses to emotional stroop in adults with autism spectrum disorders: influence of medication. | |
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MedLine Citation:
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PMID: 21360828 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Researchers have recently hypothesized that autism spectrum disorders (ASD) may be partly characterized by physiological over-arousal. One way to assess physiological arousal is through autonomic measures. Here heart period (HP) and parasympathetic activity measured by respiratory sinus arrhythmia (RSA) were examined in adults with ASD and matched controls at rest and during performance of an emotional Stroop task. Resting HP and RSA were lower in adults with ASD than in matched controls, consistent with hypothesized over-arousal in ASD. However, dividing the ASD group on the basis of antipsychotic medication usage revealed that group differences in autonomic arousal may be related to the effects of these medications or their correlates. Autonomic adjustments for Stroop performance were comparable across groups, but in the control group, larger RSA reductions were correlated with faster responding (i.e., better performance). This relation was reversed in the unmedicated ASD group and absent in the medicated ASD group. Findings highlight the importance of considering medication status in the recently burgeoning area of psychophysiological studies of autism. |
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Authors:
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Karen J Mathewson; Irene E Drmic; Michelle K Jetha; Susan E Bryson; Joel O Goldberg; Geoffrey B Hall; Diane L Santesso; Sidney J Segalowitz; Louis A Schmidt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-28 |
Journal Detail:
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Title: Autism research : official journal of the International Society for Autism Research Volume: - ISSN: 1939-3806 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101461858 Medline TA: Autism Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011, International Society for Autism Research, Wiley Periodicals, Inc. |
Affiliation:
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Department of Psychology, Neuroscience & Behavior, McMaster University, Hamilton, Ontario, Canada. mathewkj@mcmaster.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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