Document Detail


Behavioral and biochemical effects of the dopamine D3 receptor-selective ligand, 7-OH-DPAT, in the normal and the reserpine-treated rat.
MedLine Citation:
PMID:  7988642     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In normal rats, the dopamine D3 receptor-selective ligand, 7-hydroxy-2-(di-n-propylamino)tetralin (7-OH-DPAT), produced biphasic effects on spontaneous locomotor activity, i.e. suppression at low doses (0.06-0.25 mumol kg-1 s.c.), followed by a gradual increase in motor activity (1.0-4.0 mumol kg-1). The core temperature was decreased at these latter high doses only. The reserpine-induced (8.2 mumol kg-1 s.c.) increase in neostriatal 3,4-dihydroxyphenylalanine (DOPA) accumulation, following treatment with m-hydroxybenzylhydrazine-(NSD-1015) (475 mumol kg-1 i.p.), was dose dependently antagonized by 7-OH-DPAT in the dose range 0.02-4.0 mumol kg-1. The reserpine-induced suppression of spontaneous locomotor activity, however, was antagonized at higher doses only (1.0-4.0 mumol kg-1). Finally, there were no region-selective effects of 7-OH-DPAT on DOPA accumulation in the neostriatum. Thus, it appears that the dopamine D3 receptor-preferring ligand, 7-OH-DPAT, displays the profile of a dopamine D2 receptor agonist, pre- and postsynaptically.
Authors:
S Ahlenius; P Salmi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  260     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-09     Completed Date:  1995-01-09     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  177-81     Citation Subset:  IM    
Affiliation:
Department of Behavioral Pharmacology, Astra Arcus AB, Södertälje, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Binding Sites
Body Temperature / drug effects
Dihydroxyphenylalanine / metabolism
Dopa Decarboxylase / antagonists & inhibitors
Dose-Response Relationship, Drug
Hydrazines / pharmacology
Injections, Subcutaneous
Ligands
Male
Motor Activity / drug effects*
Neostriatum / drug effects*,  metabolism
Rats
Rats, Sprague-Dawley
Receptors, Dopamine / metabolism
Receptors, Dopamine D2*
Receptors, Dopamine D3
Reserpine / pharmacology*
Tetrahydronaphthalenes / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
0/Drd3 protein, rat; 0/Hydrazines; 0/Ligands; 0/Receptors, Dopamine; 0/Receptors, Dopamine D2; 0/Receptors, Dopamine D3; 0/Tetrahydronaphthalenes; 50-55-5/Reserpine; 63-84-3/Dihydroxyphenylalanine; 637-33-2/3-hydroxybenzylhydrazine; 74938-11-7/7-hydroxy-2-N,N-dipropylaminotetralin; EC 4.1.1.-/Dopa Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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