Document Detail


Behavioral and biochemical effect of chronic treatment with D-1 and/or D-2 dopamine agonists in MPTP monkeys.
MedLine Citation:
PMID:  3261249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monkeys developed a severe parkinsonian syndrome after intravenous administration of (MPTP). L-DOPA/carbidopa (D-1 and D-2) or bromocriptine (D-2) treatment relieved the parkinsonian symptoms, whereas SKF 38393 (D-1) was ineffective. No dyskinesia was seen in monkeys receiving bromocriptine or SKF 38393 as opposed to the L-DOPA-treated animals, in which the dyskinetic response appeared to increased with time. MPTP induced a significant increase (25%, P less than 0.01) in the number of [3H]spiperone binding sites (Bmax) in the caudate nucleus and in putamen. The Bmax of spiperone binding in the L-DOPA-treated monkeys was on average 18% lower (P less than 0.01) than that of the animals treated with MPTP alone. The Bmax for the bromocriptine-treated group was 29% (P less than 0.01) less than that in the MPTP-treated group or 11% (P less than 0.05) less than that in the L-DOPA-treated monkeys. The SKF 38393 treatment induced a 23% (P less than 0.01) decrease in the Bmax as compared to that of animals treated with MPTP alone, and no significant change compared to the L-DOPA- or bromocriptine-treated animals. These results suggest that stimulation of D-1 and D-2 dopamine receptors can differently influence the mechanisms controlling dopamine agonist-induced dyskinesia in MPTP-treated monkeys.
Authors:
P Falardeau; S Bouchard; P J Bédard; R Boucher; T Di Paolo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  150     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-09-16     Completed Date:  1988-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  IM    
Affiliation:
School of Pharmacy, Laval University, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
3,4-Dihydroxyphenylacetic Acid / metabolism
Animals
Apomorphine / pharmacology
Benzazepines / pharmacology
Brain Chemistry / drug effects*
Dopamine / metabolism
Dyskinesia, Drug-Induced / metabolism,  physiopathology
Female
Homovanillic Acid / metabolism
Macaca fascicularis
Motor Activity / drug effects*
Parkinson Disease, Secondary / chemically induced*,  metabolism,  physiopathology
Pyridines / toxicity*
Receptors, Dopamine / metabolism*
Spiperone / metabolism
Chemical
Reg. No./Substance:
0/Benzazepines; 0/Pyridines; 0/Receptors, Dopamine; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 306-08-1/Homovanillic Acid; 58-00-4/Apomorphine; 67287-49-4/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 749-02-0/Spiperone

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