| Behavioral aspects of GABAergic-dopaminergic interactions in the central nervous system. | |
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MedLine Citation:
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PMID: 2776839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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GABAergic-dopaminergic relationships in rats were analysed quantitatively by means of behavioral studies. Acute and long-term haloperidol administration induced significant leftward displacement of the control dose-response curves for picrotoxin but not those for strychnine or 3-mercaptopropionic acid (3-MPA). Apomorphine given acutely increased the sensitivity of the animal to strychnine but not to picrotoxin or 3-MPA. In animals that presented convulsion a stereotyped gnawing and/or licking behavior was observed immediately after the ictus activity as a consequence of the combined acute administration of haloperidol and picrotoxin. Long-term haloperidol treatment increased the gnawing and/or licking behavior immediately before and/or after the ictus activity induced by picrotoxin (1 and 72 h after haloperidol withdrawal) or 3-MPA (72 h after withdrawal). A possible effect of the drugs employed on the DA-nigroamygdaloid and/or the GABA-striatonigral fiber systems is discussed. |
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Authors:
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M R Sandoval; J Palermo-Neto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 167 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-10-26 Completed Date: 1989-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 117-25 Citation Subset: IM |
Affiliation:
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Laboratory of Pharmacology Instituto Butantan, School of Veterinary Medicine, University of São Paulo, Brasil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Mercaptopropionic Acid
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pharmacology Animals Dopamine / physiology* Haloperidol / pharmacology Male Picrotoxin / pharmacology Rats Rats, Inbred Strains Seizures / chemically induced, physiopathology* Stereotyped Behavior* / drug effects Strychnine / pharmacology Time Factors gamma-Aminobutyric Acid / physiology* |
| Chemical | |
Reg. No./Substance:
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107-96-0/3-Mercaptopropionic Acid; 124-87-8/Picrotoxin; 52-86-8/Haloperidol; 56-12-2/gamma-Aminobutyric Acid; 57-24-9/Strychnine |
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