| Behavioral alterations in response to fear-provoking stimuli and tranylcypromine induced by perinatal exposure to bisphenol A and nonylphenol in male rats. | |
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MedLine Citation:
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PMID: 15289160 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to examine whether perinatal exposure to two major environmental endocrine-disrupting chemicals, bisphenol A (BPA; 0.1 mg/kg/day orally) and nonylphenol [NP; 0.1 mg/kg/day (low dose) and 10 mg/kg/day (high dose) orally] daily from gestational day 3 to postnatal day 20 (transplacental and lactational exposures) would lead to behavioral alterations in the male offspring of F344 rats. Neither BPA nor NP exposure affected behavioral characteristics in an open-field test (8 weeks of age), in a measurement of spontaneous motor activity (12 weeks of age), or in an elevated plus-maze test (14 weeks of age). A passive avoidance test (13 weeks of age) showed that both BPA- and NP-treated offspring tended to delay entry into a dark compartment. An active avoidance test at 15 weeks of age revealed that BPA-treated offspring showed significantly fewer avoidance responses and low-dose NP-treated offspring exhibited slightly fewer avoidance responses. Furthermore, BPA-treated offspring significantly increased the number of failures to avoid electrical unconditioned stimuli within 5-sec electrical shock presentation compared with the control offspring. In a monoamine-disruption test using 5 mg/kg (intraperitoneal) tranylcypromine (Tcy), a monoamine oxidase inhibitor, both BPA-treated and low-dose NP-treated offspring at 22-24 weeks of age failed to show a significant increment in locomotion in response to Tcy, whereas control and high-dose NP-treated offspring significantly increased locomotion behavior after Tcy injection. In addition, when only saline was injected during a monoamine-disruption test, low-dose NP-treated offspring showed frequent rearing compared with the control offspring. The present results indicate that perinatal low-dose BPA or NP exposure irreversibly influenced the reception of fear-provoking stimuli (e.g., electrical shock), as well as monoaminergic neural pathways. Key words: behavior, bisphenol A, fear, learning, monoamine, nonylphenol. |
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Authors:
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Takayuki Negishi; Katsuyoshi Kawasaki; Shingo Suzaki; Haruna Maeda; Yoshiyuki Ishii; Shigeru Kyuwa; Yoichiro Kuroda; Yasuhiro Yoshikawa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Environmental health perspectives Volume: 112 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-03 Completed Date: 2004-10-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: United States |
Other Details:
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Languages: eng Pagination: 1159-64 Citation Subset: IM |
Affiliation:
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Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. taka-u@yayoi.club.ne.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Age Factors Animals Anti-Anxiety Agents / administration & dosage, pharmacology Avoidance Learning / drug effects* Dose-Response Relationship, Drug Estrogens, Non-Steroidal / toxicity* Fear* Female Male Maternal-Fetal Exchange Phenols / toxicity* Pregnancy Prenatal Exposure Delayed Effects* Rats Rats, Inbred F344 Tranylcypromine / administration & dosage, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Estrogens, Non-Steroidal; 0/Phenols; 155-09-9/Tranylcypromine; 25154-52-3/nonylphenol; 80-05-7/bisphenol A |
| Comments/Corrections | |
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