| Behavioral adjustment in a community sample of boys: links with basal and stress-induced salivary cortisol concentrations. | |
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MedLine Citation:
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PMID: 20223598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been observed in association with internalizing symptoms and is thought to be involved in the pathogenesis of depression and some anxiety disorders. This study examined basal and stress-induced cortisol concentrations in relation to internalizing and externalizing symptoms in a racially mixed community sample of 102 8-11-year-old boys. Afternoon basal cortisol concentrations were positively correlated with measures of internalizing behavior problems, social problems, and emotionality. Greater change in cortisol across a home-visit challenge task was also significantly associated with internalizing behaviors and social problems, as well as attention and thought problems. The implications of these findings and how they may relate to the pathogenesis of emotional and behavioral problems are discussed. |
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Authors:
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Audrey R Tyrka; Megan M Kelly; Julia A Graber; Laura DeRose; Janet K Lee; Michelle P Warren; Jeanne Brooks-Gunn |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural Date: 2010-03-11 |
Journal Detail:
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Title: Psychoneuroendocrinology Volume: 35 ISSN: 1873-3360 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-14 Revised Date: 2011-10-31 |
Medline Journal Info:
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Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: England |
Other Details:
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Languages: eng Pagination: 1167-77 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Butler Hospital, Providence, RI 02906, USA. Audrey_Tyrka@Brown.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Psychological
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physiology Child Child Behavior / physiology* Circadian Rhythm House Calls Humans Hydrocortisone / analysis, metabolism* Male Osmolar Concentration Residence Characteristics Saliva / chemistry, metabolism* Social Adjustment* Stress, Psychological / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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1 K23 MH067947/MH/NIMH NIH HHS; K23 MH067947-05/MH/NIMH NIH HHS; MH56557/MH/NIMH NIH HHS; R01 MH056557-05/MH/NIMH NIH HHS; R24 HD047879-06/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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