| Behavioral and neurophysiological effects of repetitive transcranial magnetic stimulation on the minimally conscious state: a case study. | |
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MedLine Citation:
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PMID: 20647501 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: In 2007, Schiff et al reported a patient in a minimally conscious state (MCS) who responded to deep brain stimulation (DBS), but clinicians cannot predict which patients might respond prior to the implantation of electrodes. METHODS: A patient in a MCS for 5 years participated in an ABA design alternating between repetitive transcranial magnetic stimulation (rTMS) and peripheral nerve stimulation. rTMS (condition A) involved the delivery of 10 trains of 100 stimuli at 20 Hz using a stimulator with a 70-mm figure-of-eight coil to elicit a contraction of the abductor pollicis brevis. Condition B used median nerve electrical stimulation. RESULTS: After peripheral stimulation, the patient did not exhibit clinical, behavioral, or electroencephalographic (EEG) changes. The frequency of specific and meaningful behaviors increased after rTMS, along with the absolute and relative power of the EEG δ, β, and α bands. CONCLUSION: These results suggest that rTMS may improve awareness and arousal in MCS. If these results are reproducible, rTMS may identify subgroups of MCS patients who might benefit from DBS. |
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Authors:
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Francesco Piccione; Marianna Cavinato; Paolo Manganotti; Emanuela Formaggio; Silvia Francesca Storti; Leontino Battistin; Annachiara Cagnin; Paolo Tonin; Mauro Dam |
Publication Detail:
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Type: Journal Article Date: 2010-07-20 |
Journal Detail:
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Title: Neurorehabilitation and neural repair Volume: 25 ISSN: 1552-6844 ISO Abbreviation: Neurorehabil Neural Repair Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892086 Medline TA: Neurorehabil Neural Repair Country: United States |
Other Details:
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Languages: eng Pagination: 98-102 Citation Subset: IM |
Affiliation:
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Department of Neurorehabilitation, IRCCS S. Camillo, Venice, Italy. francesco.piccione@ospedalesancamillo.net |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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