Document Detail


Behavioral differences between late preweanling and adult female Sprague-Dawley rat exploration of animate and inanimate stimuli and food.
MedLine Citation:
PMID:  21056059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The late preweanling rat has potential as a preclinical model for disorders initially manifested in early childhood that are characterized by dysfunctional interactions with specific stimuli (e.g., obsessive-compulsive disorder and autism). No reports, however, of specific-stimulus exploration in the late preweanling rat are found in the literature. We examined the behavioral responses of normal late preweanling (PND 18-19) and adult rats when presented with exemplars of categorically-varied stimuli, including inanimate objects systematically varied in size and interactive properties, biological stimuli, and food. Preweanlings were faster to initiate specific stimulus exploration and were more interactive with most specific stimuli than adults; the magnitude of these preweanling-adult quantitative differences ranged from fairly small to very large depending upon the stimulus. In contrast, preweanlings were adult-like in their interaction with food and prey. Preweanling response to some stimuli, for example to live pups, was qualitatively different from that of adults; the preweanling behavioral repertoire was characterized by pup-seeking while the adult response was characterized by pup-avoidance. The specific stimulus interactions of preweanlings were less impacted than those of adults by the time of day of testing and placement of a stimulus in an anxiety-provoking location. The impact of novelty was stimulus dependent. The differences in interactions of preweanlings versus adults with specific stimuli suggests that CNS systems underlying these behavior patterns are at different stages of immaturity at PND 18 such that there may be an array of developmental trajectories for various categories of specific stimuli. These data provide a basis for the use of the preweanling as a preclinical model for understanding and medicating human disorders during development that are characterized by dysfunctional interactions with specific stimuli.
Authors:
Kiersten S Smith; Joan I Morrell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-11-04
Journal Detail:
Title:  Behavioural brain research     Volume:  217     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2010-12-27     Completed Date:  2011-04-18     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  326-36     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aging / psychology*
Analysis of Variance
Animals
Animals, Newborn
Animals, Suckling
Behavior, Animal
Circadian Rhythm
Exploratory Behavior / physiology*
Feeding Behavior / physiology*
Female
Food Deprivation / physiology
Interpersonal Relations*
Motor Activity / physiology
Rats
Rats, Sprague-Dawley
Social Environment*
Grant Support
ID/Acronym/Agency:
5 R25 GM060826-06/GM/NIGMS NIH HHS; DA 014025/DA/NIDA NIH HHS; R01 DA014025/DA/NIDA NIH HHS; R01 DA014025-07/DA/NIDA NIH HHS; R25 GM060826/GM/NIGMS NIH HHS; R25 GM060826-06/GM/NIGMS NIH HHS
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