Document Detail

Behavior of postextrasystolic His-Purkinje system refractoriness after multiple premature beats.
MedLine Citation:
PMID:  2450937     Owner:  NLM     Status:  MEDLINE    
Although the steady-state refractoriness of the human His-Purkinje system has been shown to be directly related to the cycle length of pacing, the effect that a varying number of premature beats would have on His-Purkinje system refractoriness of the first postextrasystolic beat has not been described. These effects were systematically investigated in 10 patients with normal intraventricular conduction. The His-Purkinje system relative refractory period (HPS-RRP) of the postextrasystolic beat and that of a comparable constant cycle length ventricular drive were measured by the ventricular extrastimulus technique. Results were as follows: the HPS-RRP of the postextrasystolic beat after one premature beat was longer than the HPS-RRP during a comparable constant ventricular drive. However, with the addition of each successive premature beat, the HPS-RRP of the postextrasystolic beat alternated between lower and higher values, in a manner dependent on whether there was an odd or even number of premature beats. In contrast, ventricular refractoriness of the postextrasystolic beats behaved in a cumulative manner, decreasing progressively with the addition of each premature beat.
P Tchou; M H Lehmann; R Mahmud; J Dongas; S Denker; M Akhtar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  111     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-05-11     Completed Date:  1988-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-15     Citation Subset:  AIM; IM    
Natalie and Norman Soref and Family Electrophysiology Laboratory, University of Wisconsin-Mount Sinai Medical Center, Milwaukee.
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MeSH Terms
Bundle of His / physiopathology*
Cardiac Complexes, Premature / physiopathology*
Heart Conduction System / physiopathology*
Heart Ventricles
Neural Conduction*
Purkinje Fibers / physiopathology*
Refractory Period, Electrophysiological*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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