Document Detail

Behavior of mitral allografts in the tricuspid position in the growing sheep model.
MedLine Citation:
PMID:  9594861     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: On the basis of a previous experience in a chronic sheep model in which partial mitral allografts remained viable and properly functioning 12 months after operation, we assessed the results obtained by replacing the tricuspid valve with fresh antibiotic-preserved mitral allografts. METHODS: Twenty 3-month-old sheep with a mean weight of 23.7 +/- 2.3 kg underwent cardiopulmonary bypass and had a fresh antibiotic-preserved mitral allograft implanted in the tricuspid position with the heart beating under normothermic conditions. The tricuspid valve apparatus was not excised. After a mean follow-up of 13.2 months, the allograft was evaluated by gross inspection and light and electron microscopy. RESULTS: Nine sheep died of technical causes within the first week after operation and 2 at 4 and 6 months of infective endocarditis of the allograft. The hemodynamic study before heart explantation revealed residual tricuspid incompetence in 3 of the 9 survivors. Macroscopic examination showed flexible valves with no signs of structural deterioration, calcification, or thrombosis. Under light and scanning electron microscopic examination, allografts were almost completely denuded of endothelial cells and showed loosely arranged connective tissue with scarce signs of inflammatory reaction. Despite these findings, allografts were free from major structural damage. CONCLUSIONS: The mitral homograft could be an alternative to replacement of the tricuspid valve with a bioprosthesis or a mechanical prosthesis.
J M Bernal; J M Rabasa; J C Cagigas; F Val; J M Revuelta
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  65     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-10     Completed Date:  1998-06-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1326-30     Citation Subset:  AIM; IM    
Department of Cardiovascular Surgery, Hospital Universitario Valdecilla, Universidad de Cantabria, Santander, Spain.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Calcinosis / pathology
Cardiopulmonary Bypass
Cause of Death
Connective Tissue / pathology
Disease Models, Animal
Endocarditis, Bacterial / etiology
Endothelium, Vascular / pathology
Follow-Up Studies
Graft Survival
Heart Valve Prosthesis Implantation
Microscopy, Electron, Scanning
Mitral Valve / pathology,  transplantation*,  ultrastructure
Organ Preservation
Surgical Wound Infection / etiology
Survival Rate
Thrombosis / pathology
Transplantation, Homologous
Tricuspid Valve / surgery*
Tricuspid Valve Insufficiency / physiopathology,  surgery
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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