| Behavior of mitral allografts in the tricuspid position in the growing sheep model. | |
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MedLine Citation:
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PMID: 9594861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: On the basis of a previous experience in a chronic sheep model in which partial mitral allografts remained viable and properly functioning 12 months after operation, we assessed the results obtained by replacing the tricuspid valve with fresh antibiotic-preserved mitral allografts. METHODS: Twenty 3-month-old sheep with a mean weight of 23.7 +/- 2.3 kg underwent cardiopulmonary bypass and had a fresh antibiotic-preserved mitral allograft implanted in the tricuspid position with the heart beating under normothermic conditions. The tricuspid valve apparatus was not excised. After a mean follow-up of 13.2 months, the allograft was evaluated by gross inspection and light and electron microscopy. RESULTS: Nine sheep died of technical causes within the first week after operation and 2 at 4 and 6 months of infective endocarditis of the allograft. The hemodynamic study before heart explantation revealed residual tricuspid incompetence in 3 of the 9 survivors. Macroscopic examination showed flexible valves with no signs of structural deterioration, calcification, or thrombosis. Under light and scanning electron microscopic examination, allografts were almost completely denuded of endothelial cells and showed loosely arranged connective tissue with scarce signs of inflammatory reaction. Despite these findings, allografts were free from major structural damage. CONCLUSIONS: The mitral homograft could be an alternative to replacement of the tricuspid valve with a bioprosthesis or a mechanical prosthesis. |
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Authors:
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J M Bernal; J M Rabasa; J C Cagigas; F Val; J M Revuelta |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 65 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-06-10 Completed Date: 1998-06-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1326-30 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiovascular Surgery, Hospital Universitario Valdecilla, Universidad de Cantabria, Santander, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / therapeutic use Calcinosis / pathology Cardiopulmonary Bypass Cause of Death Connective Tissue / pathology Disease Models, Animal Endocarditis, Bacterial / etiology Endothelium, Vascular / pathology Follow-Up Studies Graft Survival Growth Heart Valve Prosthesis Implantation Hemodynamics Microscopy, Electron, Scanning Mitral Valve / pathology, transplantation*, ultrastructure Organ Preservation Sheep Surgical Wound Infection / etiology Survival Rate Thrombosis / pathology Transplantation, Homologous Tricuspid Valve / surgery* Tricuspid Valve Insufficiency / physiopathology, surgery |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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