Document Detail


Behavior-dependent specialization of identified hippocampal interneurons.
MedLine Citation:
PMID:  22864613     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A large variety of GABAergic interneurons control information processing in the hippocampal circuits governing the formation of neuronal representations. Whether distinct hippocampal interneuron types contribute differentially to information processing during behavior is not known. We employed a new technique for recording and labeling interneurons and pyramidal cells in drug-free, freely moving rats. Recorded parvalbumin-expressing basket interneurons innervated somata and proximal pyramidal cell dendrites, whereas nitric oxide synthase- and neuropeptide Y-expressing ivy cells provided synaptic and extrasynaptic dendritic modulation. Basket and ivy cells showed distinct spike-timing dynamics, firing at different rates and times during theta and ripple oscillations. Basket, but not ivy, cells changed their firing rates during movement, sleep and quiet wakefulness, suggesting that basket cells coordinate cell assemblies in a behavioral state-contingent manner, whereas persistently firing ivy cells might control network excitability and homeostasis. Different interneuron types provide GABA to specific subcellular domains at defined times and rates, thereby differentially controlling network activity during behavior.
Authors:
Damien Lapray; Balint Lasztoczi; Michael Lagler; Tim James Viney; Linda Katona; Ornella Valenti; Katja Hartwich; Zsolt Borhegyi; Peter Somogyi; Thomas Klausberger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-05
Journal Detail:
Title:  Nature neuroscience     Volume:  15     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-30     Completed Date:  2012-11-05     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1265-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Axons / physiology
Behavior, Animal / physiology*
Dendrites / physiology
Electric Stimulation
Electrodes, Implanted
Electroencephalography
Electrophysiological Phenomena
Evoked Potentials / physiology
Hippocampus / cytology,  physiology*
Immunohistochemistry
Interneurons / physiology*
Microscopy, Electron
Nerve Net / cytology,  physiology
Nerve Tissue Proteins / biosynthesis,  genetics
Parvalbumins / metabolism
Pyramidal Cells / physiology
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
242689//European Research Council; MC_U138197107//Medical Research Council; MC_U138197110//Medical Research Council; U.1055(97110)//Medical Research Council
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Parvalbumins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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