| Behavior and cognition in corticobasal degeneration and progressive supranuclear palsy. | |
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MedLine Citation:
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PMID: 19733862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), previously described as Parkinsonian syndromes are also cognitive disorders, and biologically related to the frontotemporal dementia or Pick's disease. PSP and CBD overlap clinically, pathologically and genetically, sharing tau haplotypes and mutations. In our series of CBD/PSP patients with cognitive presentation (n=36), primary progressive aphasia (PPA) was particularly common, but behavioral onset occurred also. CBD or PSP as motor presentations developed significant language disorder in 17/19. The underlying pathology is predictably tau positive in these clinical combinations, regardless of the presentation. Other cognitive features of CBDS include apraxia, alien hand and apathy, but often frontal lobe dementia with disinhibition develops also. CBDS also has visuospatial deficit, because of the parietal involvement. PSP was considered the prototype of subcortical dementia, with bradyphrenia, poor recall and executive deficit, but cortical features were recognized to be important also. Language testing and a behavioral inventory should be part of neuropsychological tests to facilitate diagnosis and to quantify the deficit. The clinical, genetic and pathological relationship is strong between CBD /PSP and the aphasic and behavioral components of the Pick complex. |
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Authors:
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Andrew Kertesz; Paul McMonagle |
Publication Detail:
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Type: Journal Article Date: 2009-09-05 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 289 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-28 Completed Date: 2010-04-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 138-43 Citation Subset: IM |
Affiliation:
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Dept of Cognitive Neurology, University of Western Ontario, St Joseph's Hospital, Ontario, Canada. Andrew.Kertesz@sjhc.london.on.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Basal Ganglia
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pathology* Behavioral Symptoms / classification, etiology* Cerebral Cortex / pathology* Cognition Disorders / classification, etiology* Humans Language Disorders / etiology Neurodegenerative Diseases / complications*, pathology* Neuropsychological Tests Personality Inventory Supranuclear Palsy, Progressive / complications* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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