Document Detail

Behavior of ADAMTS13 and Von Willebrand factor levels in patients after living donor liver transplantation.
MedLine Citation:
PMID:  23266519     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Thrombotic microangiopathy (TMA) is one of the important complications occurring after liver transplantation (LT), and it is suggested that a Von Willebrand factor (VWF) and ADAMTS13 may play an important role in the onset of TMA and poor outcome after LT. MATERIALS AND METHODS: In 81 patients after living donor LT (LDLT), 17 patients who had both severe thrombocytopenia and hemolytic anemia with fragmented red cell were diagnosed as TMA- like syndrome (TMALS) and 10 patients died. RESULTS: ADAMTS13 activities were slightly low, and plasma levels of VWF and VWF propeptide (VWFpp) antigens and the ratio of VWFpp/VWF were significantly high before LDLT. ADAMTS13 activities were significantly reduced from day 1 to day 28 after surgery, and plasma levels of VWF antigen slightly decreased on day 1 and plasma levels of VWFpp continued to be high. The ratio of VWFpp/VWF was significantly high on day 1 after surgery. The mortality was high in the patients with TMALS and the frequency of TMALS was high in non-survivors. VWF levels were significantly low and the ratio of VWFpp/VWF was significantly high in those with TMALS on day 1 after surgery. The ADAMTS13 activity was significantly low, and the VWFpp and the VWFpp/ADAMTS13 ratio were significantly high in non-survivor on day 28 after surgery. CONCLUSION: These findings suggest that VWF and ADAMTS13 might therefore play an important role in the onset of TMA and poor outcome after LT. The VWFpp may therefore be a more useful marker for the diagnosis of TMALS than VWF.
Naoki Takahashi; Hideo Wada; Masanobu Usui; Toshihiko Kobayashi; Naomi Habe-Ito; Takeshi Matsumoto; Shinji Uemoto; Tsutomu Nobori; Shuji Isaji
Related Documents :
24834129 - Effect of systemic inflammation on level of ferritin seminal in chronic renal male pati...
24903569 - Closantel plasma and milk disposition in dairy goats: assessment of drug residues in ch...
24814039 - Oral magnesium supplementation decreases c-reactive protein levels in subjects with pre...
23632999 - α1-antitrypsin phenotypes and associated serum protein concentrations in a large clini...
22932119 - Lixivaptan safely and effectively corrects serum sodium concentrations in hospitalized ...
23007069 - Blood folate concentrations analyzed by microbiological assay and chemiluminescent immu...
945709 - Choriocarcinoma with hyperthyroidism: probable identity of the thyrotropin with human c...
18202159 - Plasma polyunsaturated fatty acids and the decline of renal function.
1478639 - The abnormal conduct of capercaillies tetrao urogallus.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-21
Journal Detail:
Title:  Thrombosis research     Volume:  -     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Mie, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Thrombosis in acute promyelocytic leukemia.
Next Document:  Infectome: A platform to trace infectious triggers of autoimmunity.