Document Detail

Beetle immunity.
MedLine Citation:
PMID:  21528698     Owner:  NLM     Status:  MEDLINE    
Genetic studies have elegantly characterized the innate immune response in Drosophila melanogaster. However, these studies have a limited ability to reveal the biochemical mechanisms underlying the innate immune response. To investigate the biochemical basis of how insects recognize invading microbes and how these recognition signals activate the innate immune response, it is necessary to use insects, from which larger amounts of hemolymph can be extracted. Using the larvae from two species of beetle, Tenebrio molitor and Holotrichia diomphalia, we elucidated the mechanisms underlying pathogenic microbe recognition. In addition, we studied the mechanism of host defense molecule amplification. In particular, we identified several pattern recognition proteins, serine proteases, serpins and antimicrobial peptides and examined how these molecules affect innate immunity.
Ji-Won Park; Chan-Hee Kim; Jiang Rui; Keun-Hwa Park; Kyung-Hwa Ryu; Jun-Ho Chai; Hyun-Ok Hwang; Kenji Kurokawa; Nam-Chul Ha; Irene Söderhill; Kenneth Söderhill; Bok Luel Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  708     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-05-19     Revised Date:  2011-12-20    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-80     Citation Subset:  IM    
National Research Laboratory of Defense Proteins, College of Pharmacy, Pusan National University, Busan, Korea.
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MeSH Terms
Amino Acid Sequence
Beetles / genetics,  immunology*
Hemolymph / immunology
Immunity / immunology
Molecular Sequence Data
Receptors, Pattern Recognition / genetics,  immunology
Signal Transduction / immunology
Reg. No./Substance:
0/Receptors, Pattern Recognition

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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