Document Detail

Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium.
MedLine Citation:
PMID:  17953789     Owner:  NLM     Status:  MEDLINE    
Red meat consumption is associated with increased risk of colorectal cancer. We have previously shown that haemin, Hb and red meat promote carcinogen-induced preneoplastic lesions: aberrant crypt foci (ACF) and mucin-depleted foci (MDF) in rats. We have also shown that dietary Ca, antioxidant mix and olive oil inhibit haemin-induced ACF promotion, and normalize faecal lipoperoxides and cytotoxicity. Here we tested if these strategies are effective also against red meat promotion in dimethylhydrazine-induced rats. Three diets with 60 % beef meat were supplemented with calcium phosphate (31 g/kg), antioxidant agents (rutin and butylated hydroxyanisole, 0.05 % each) and olive oil (5 %). ACF, MDF, faecal water cytotoxicity, thiobarbituric acid reactive substances (TBARS) and urinary 1,4-dihydroxynonane mercapturic acid (DHN-MA) were measured. Beef meat diet increased the number of ACF (+30 %) and MDF (+100 %) (P < 0.001), which confirms our previous findings. Promotion was associated with increased faecal water TBARs ( x 4) and cytotoxicity ( x 2), and urinary DHN-MA excretion ( x 15). Ca fully inhibited beef meat-induced ACF and MDF promotion, and normalized faecal TBARS and cytotoxicity, but did not reduce urinary DHN-MA. Unexpectedly, high-calcium control diet-fed rats had more MDF and ACF in the colon than low-Ca control diet-fed rats. Antioxidant mix and olive oil did not normalize beef meat promotion nor biochemical factors. The results confirm that haem causes promotion of colon carcinogenesis by red meat. They suggest that Ca can reduce colorectal cancer risk in meat-eaters. The results support the concept that toxicity associated with the excess of a useful nutrient may be prevented by another nutrient.
Fabrice Pierre; Raphaëlle Santarelli; Sylviane Taché; Françoise Guéraud; Denis E Corpet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-22
Journal Detail:
Title:  The British journal of nutrition     Volume:  99     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2009-03-03     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1000-6     Citation Subset:  IM    
UMR1089 Xénobiotiques, INRA-ENVT, 23 ch Capelles, Toulouse, France.
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MeSH Terms
Acetylcysteine / analogs & derivatives,  urine
Antioxidants / therapeutic use
Body Weight / drug effects
Calcium, Dietary / therapeutic use*
Cell Transformation, Neoplastic / drug effects
Colorectal Neoplasms / etiology,  metabolism,  prevention & control*
Eating / drug effects
Feces / chemistry
Heme / metabolism
Meat / adverse effects*
Plant Oils / therapeutic use
Rats, Inbred F344
Thiobarbituric Acid Reactive Substances / metabolism
Reg. No./Substance:
0/1,4-dihydroxynonene mercapturic acid; 0/Antioxidants; 0/Calcium, Dietary; 0/Plant Oils; 0/Thiobarbituric Acid Reactive Substances; 14875-96-8/Heme; 540-73-8/1,2-Dimethylhydrazine; 616-91-1/Acetylcysteine; 8001-25-0/olive oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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