Document Detail


Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration.
MedLine Citation:
PMID:  18059136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pigmentation may result from melanocyte proliferation, melanogenesis, migration or increases in dendricity. Recently, it has been reported that secreted phospholipase A(2)(sPLA(2)) known as a component of bee venom (BV), stimulates melanocyte dendricity and pigmentation. BV has been used clinically to control rheumatoid arthritis and to ameliorate pain via its anti-inflammatory and antinociceptive properties. Moreover, after treatment with BV, pigmentation around the injection sites was occasionally observed and the pigmentation lasted a few months. However, no study has been done about the effect of BV on melanocytes. Thus, in the present study, we examined the effect of BV on the proliferation, melanogenesis, dendricity and migration in normal human melanocytes and its signal transduction. BV increased the number of melanocytes dose and time dependently through PKA, ERK, and PI3K/Akt activation. The level of cAMP was also increased by BV treatment. Moreover, BV induced melanogenesis through increased tyrosinase expression. Furthermore, BV induced melanocyte dendricity and migration through PLA(2) activation. Overall, in this study, we demonstrated that BV may have an effect on the melanocyte proliferation, melanogenesis, dendricity and migration through complex signaling pathways in vitro, responsible for the pigmentation. Thus, our study suggests a possibility that BV may be developed as a therapeutic drug for inducing repigmentation in vitiligo skin.
Authors:
Songhee Jeon; Nan Hyung Kim; Byung Soo Koo; Hyun Joo Lee; Ai Young Lee
Related Documents :
8535646 - The antirheumatic agents sulphasalazine and methotrexate share an anti-inflammatory mec...
15005296 - Intra-articular hyaluronans in knee osteoarthritis: rationale and practical considerati...
9597336 - Pharmacologic management of periodontal diseases using systemically administered agents.
2891456 - Urinary enzyme activities in patients treated with gold and other antirheumatic drugs.
16721796 - Stability profiles of drug products extended beyond labeled expiration dates.
21219406 - Case series on a diversity of illicit weight-reducing agents: from the well known to th...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental & molecular medicine     Volume:  39     ISSN:  1226-3613     ISO Abbreviation:  Exp. Mol. Med.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607880     Medline TA:  Exp Mol Med     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  603-13     Citation Subset:  IM    
Affiliation:
Dongguk University Research Institute of Biotechnology, Medical Science Research Center, Goyang 410-773, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Bee Venoms / pharmacology*
Cell Movement / drug effects
Cell Proliferation / drug effects
Cells, Cultured
Cyclic AMP / metabolism
DNA Primers / genetics
Forskolin / pharmacology
Gene Expression / drug effects
Humans
Melanins / biosynthesis
Melanocytes / cytology,  drug effects*,  physiology
Microphthalmia-Associated Transcription Factor / biosynthesis,  genetics
Monophenol Monooxygenase / biosynthesis,  genetics
Signal Transduction / drug effects
Chemical
Reg. No./Substance:
0/Bee Venoms; 0/DNA Primers; 0/MITF protein, human; 0/Melanins; 0/Microphthalmia-Associated Transcription Factor; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin; EC 1.14.18.1/Monophenol Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Homo-dimerization of RyR1 C-terminus via charged residues in random coils or in an alpha-helix.
Next Document:  Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema.