Document Detail

Bedside assessment of respiratory viscoelastic properties in ventilated patients.
MedLine Citation:
PMID:  10968507     Owner:  NLM     Status:  MEDLINE    
Viscoelasticity represents an important component of respiratory mechanics, being responsible, in some cases, for most of the pressure dissipated during breathing. Hitherto the methods available for determining the viscoelastic properties have been simplified, but are still time-demanding and depend on a great deal of calculation. In this study, a simple means of determining respiratory viscoelastic properties during mechanical ventilation was introduced. The viscoelastic constants of the respiratory system, modelled as a Maxwell body, were studied in 17 normal subjects and seven patients with acute lung injury (ALI) using two end-inspiratory occlusions; one with a short inspiratory time (tI) to determine the elastic component of viscoelasticity and the other with a long tI to assess the resistive component of viscoelasticity. The results were reproducible and similar to those provided by the previously described multiple-breath method (MB). The mean+/-SD viscoelastic resistance was 5.31+/-1.50 cm H2O x L(-1) x s with the proposed method and 5.71+/-1.87 cm H2O x L(-1) x s with the MB method in normal subjects, and 8.93+/-2.82 cm H2O x L(-1) x s and 10.36+/-3.13 cm H2O x L(-1), respectively in ALI patients. The mean+/-SD viscoelastic elastance was 3.92+/-0.84 cm H2O x L(-1) and 4.94+/-1.01 cm H2O x L(-1) in normal subjects and 7.08+/-2.01 cm H2O x L(-1) and 8.21+/-1.16 cm H2O x L(-1) in ALI patients, respectively. The mean+/-SD viscoelastic time constant was 1.36+/-0.24 s and 1.17+/-0.34 s in normal subjects and 1.26+/-0.35 s and 1.24+/-0.23 in ALI patients, respectively. The method was easy to perform and applicable at the bedside in clinical routine.
V Antonaglia; A Peratoner; L De Simoni; A Gullo; J Milic-Emili; W A Zin
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  16     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-04     Completed Date:  2000-12-14     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  302-8     Citation Subset:  IM    
Dept of Anaesthesia and Intensive Care Laboratory of Respiratory Biomechanics, University of Trieste, Italy.
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MeSH Terms
Airway Resistance
Middle Aged
Models, Biological
Point-of-Care Systems*
Reference Values
Reproducibility of Results
Respiration, Artificial*
Respiratory Mechanics*

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