Document Detail

Bed rest and other determinants of bone loss during pregnancy.
MedLine Citation:
PMID:  15507924     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate patterns of bone loss during pregnancy and potential influences. STUDY DESIGN: This was a prospective study of 181 women receiving prenatal care at Magee-Womens Hospital or its auxiliary clinics in Pittsburgh, Pennsylvania, between 1992 and 1995. Bone mineral density was measured at approximately 16 and 36 weeks' gestation. RESULTS: Trabecular, but not cortical, bone loss occurred during pregnancy. Mean ultra-distal bone mineral density loss was 1.9% (95% CI 1.2-2.5) during the 20-week period. Women prescribed bed rest had an adjusted mean loss of 4.6% compared with 1.5% for women not prescribed bed rest ( P = .001) and 6-fold higher odds ( P = .001) of bone loss > or =5% during the 20-week period. Nulliparity, calcium intake < 2 000 mg/day, low weight gain, and maternal age < 21 or >30 years were more modestly associated with greater bone loss. CONCLUSION: Substantial trabecular bone loss may occur during pregnancy, particularly in women prescribed bed rest. Study of postpartum bone recovery in such women is needed.
Joanne H E Promislow; Irva Hertz-Picciotto; Margaret Schramm; Margaret Watt-Morse; John J B Anderson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  191     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-27     Completed Date:  2004-12-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1077-83     Citation Subset:  AIM; IM    
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA.
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MeSH Terms
Bed Rest*
Bone Density*
Calcium, Dietary / administration & dosage
Maternal Age
Pregnancy / physiology*
Pregnancy Trimester, First
Pregnancy Trimester, Third
Prospective Studies
Sensitivity and Specificity
Weight Gain
Grant Support
Reg. No./Substance:
0/Calcium, Dietary

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