Document Detail

Beat-to-beat heart rate and QT interval variability in first episode neuroleptic-naive psychosis.
MedLine Citation:
PMID:  19570654     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Though increased risk of sudden death in patients with schizophrenia is well-documented, the mechanisms remain unclear. Recent studies report two known risk factors for sudden cardiac death and other arrhythmias in schizophrenia, i.e., decreased RR interval variability (RRV) and increased QT interval variability (QTV). However, these studies did not control for the effects of medication. Herein, we report the results of our study comparing RRV and QTV in first episode neuroleptic-naive psychosis patients with healthy matched controls. METHODS: 24 patients with first episode neuroleptic naïve psychosis were matched with 26 healthy controls on age and gender. After an overnight fast, all participants underwent an electrocardiogram recording in the morning. RESULTS: In comparison with matched controls, patients with first episode neuroleptic-naïve psychosis had significantly increased QTV corrected for RRV, and decreased RRV. CONCLUSIONS: The observed alterations in RRV and QTV may reflect impaired cardiac autonomic function that could underlie risk for abnormal ventricular repolarization and thereby increase the risk of sudden death and other arrhythmias. Our data suggest that RRV and QTV alterations may be independent of medication effects in first episode psychosis patients.
Ripu D Jindal; Matcheri S Keshavan; Kevin Eklund; Angela Stevens; Debra M Montrose; Vikram K Yeragani
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-07-01
Journal Detail:
Title:  Schizophrenia research     Volume:  113     ISSN:  1573-2509     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-10-29     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  176-80     Citation Subset:  IM    
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
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MeSH Terms
Arrhythmias, Cardiac / etiology*
Brief Psychiatric Rating Scale
Electrocardiography / methods
Fourier Analysis
Heart Rate / physiology*
Long QT Syndrome / etiology*
Psychotic Disorders / complications*
Statistics, Nonparametric
Young Adult
Grant Support
M01 RR00056/RR/NCRR NIH HHS; MH45156/MH/NIMH NIH HHS; P50 MH045156-180014/MH/NIMH NIH HHS

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