Document Detail

Beat-to-beat QRS variability in the 12-lead ECG and the detection of coronary artery disease.
MedLine Citation:
PMID:  9817216     Owner:  NLM     Status:  MEDLINE    
The aim of this article was to study beat-to-beat QRS variability in patients with ischemia and old myocardial infarction using the 12-lead resting electrocardiogram (ECG). The variability analysis was based on beats that have been synchronized in time with an iterative alignment technique. The QRS variability was measured in patients submitted for myocardial scintigraphy. Those with a normal myocardial scintigraphy (called NO, n = 34, mean age 57 years, 23 women) were compared with a group with both myocardial infarction and exercise-induced ischemia (called ISCINF, n = 27, mean age 57 years, 5 women). The mean QRS variability was somewhat smaller in lead I in ISCINF than in NO, and there was no statistically significant difference in QRS variability among the groups in leads II, III, and V1-V6. Using a multivariate approach, the joint variability in leads I, II, II, and V1-V6 was used for calculating receiver operating characteristics based on a leave-one-out procedure. The sensitivity for detecting coronary artery disease was 75% at a specificity of 50%. It is concluded that beat-to-beat QRS variability in the 12-lead ECG does not discriminate between the presence and absence of coronary artery disease sufficiently well for clinical purposes.
L Sörnmo; B Wohlfart; J Berg; O Pahlm
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of electrocardiology     Volume:  31     ISSN:  0022-0736     ISO Abbreviation:  J Electrocardiol     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-21     Completed Date:  1999-01-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  336-44     Citation Subset:  IM    
Department of Clinical Physiology, University Hospital, Lund University, Sweden.
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MeSH Terms
Coronary Disease / physiopathology,  radionuclide imaging*
Exercise Test
Heart Rate*
Middle Aged
Radiopharmaceuticals / diagnostic use
Sensitivity and Specificity
Technetium Tc 99m Sestamibi / diagnostic use
Reg. No./Substance:
0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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