Document Detail


Bead modeling using HYDRO and SOLPRO of the conformation of multisubunit proteins: sunflower and rape-seed 11S globulins.
MedLine Citation:
PMID:  17029739     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Oil seed globulins from sunflower and rape seed are multi-subunit, oligomeric proteins whose native 11S form is a hexamer. In this work we try to determine the spatial structure in which the six subunits of 11S globulin are arranged. Experimental values of solution properties, including radius of gyration, sedimentation and diffusion coefficients and intrinsic viscosity, are compared with theoretical predictions for hexamers of various geometries. Bead model calculations of solution properties are carried out using the HYDRO and SOLPRO computer programs. A most compact shape, the regular octahedron, is the hexameric structure that fits best the experimental values.
Authors:
B Carrasco; S E Harding; J G de la Torre
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biophysical chemistry     Volume:  74     ISSN:  0301-4622     ISO Abbreviation:  Biophys. Chem.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  2006-10-10     Completed Date:  2007-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403171     Medline TA:  Biophys Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  -    
Affiliation:
Departamento de Química Física, Universidad de Murcia, 30071 Murcia, Spain.
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