| Bcl2 -938C/A polymorphism carries increased risk of biochemical recurrence after radical prostatectomy. | |
| | |
MedLine Citation:
|
PMID: 19237173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Approximately 10% to 26% of patients show biochemical failure after radical prostatectomy or radiation therapy. The importance of cell cycle and apoptosis pathways in prostate cancer has been reported. However, to our knowledge there is currently no information on the role of apoptosis and cell cycle related gene polymorphisms in prostate cancer cases. We investigated several polymorphisms related to the cell cycle and apoptosis, and their role in biochemical failure after radical prostatectomy. MATERIALS AND METHODS: We genotyped 6 single nucleotide polymorphisms in 6 genes, including p53 (rs1042522), p21 (rs1801270), MDM2 (rs2279744), PTEN (rs701848), GNAS1 (rs7121) and bcl2 (rs2279115), using polymerase chain reaction-restriction fragment length polymorphism and direct DNA sequencing in 140 patients with prostate cancer and 167 age matched controls. The association of polymorphic variants with prostate specific antigen failure in patients with prostate cancer was analyzed by Kaplan-Meier curves. RESULTS: A significant increase in the frequency of the C/C genotype of GNAS1 rs7121 was observed in patients compared with controls. Interestingly we found a significant difference in biochemical recurrence-free time between the bcl2 C/C and C/A+A/A genotypes. It was also noted that the bcl2 C/C genotype was an independent risk factor for biochemical recurrence after radical prostatectomy on multivariate analysis. There was no statistical difference in the genotype distributions of the other genes between patients and controls. CONCLUSIONS: To our knowledge this is the first report documenting that bcl2 promoter region -938 C/C genotype carriers more frequently show biochemical recurrence than -938C/A+A/A carriers. |
| | |
Authors:
|
Hiroshi Hirata; Yuji Hinoda; Nobuyuki Kikuno; Yutaka Suehiro; Varahram Shahryari; Ardalan E Ahmad; Z Laura Tabatabai; Mikio Igawa; Rajvir Dahiya |
Related Documents
:
|
17593093 - Association analysis of glutathione-s-transferase p1 (gstp1) polymorphism with urotheli... 15601643 - Association of a common variant of the casp8 gene with reduced risk of breast cancer. 15064933 - Assessment of gastrointestinal function and response to megesterol acetate in subjects ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-02-23 |
Journal Detail:
|
Title: The Journal of urology Volume: 181 ISSN: 1527-3792 ISO Abbreviation: J. Urol. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-03-19 Completed Date: 2009-04-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
|
Languages: eng Pagination: 1907-12 Citation Subset: AIM; IM |
Affiliation:
|
Department of Urology, San Francisco Veterans Affairs Medical Center and University of California-San Francisco, San Francisco, California, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Humans Male Neoplasm Recurrence, Local / blood, genetics* Polymorphism, Genetic* Prostate-Specific Antigen / blood Prostatectomy* Prostatic Neoplasms / blood, genetics*, surgery* Proto-Oncogene Proteins c-bcl-2 / genetics* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
|
R01CA101844/CA/NCI NIH HHS; R01CA108612/CA/NCI NIH HHS; R01CA111470/CA/NCI NIH HHS; T32-DK07790/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Proto-Oncogene Proteins c-bcl-2; EC 3.4.21.77/Prostate-Specific Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of flow characteristics of 3-way catheters.
Next Document: Mechanisms of action of eicosapentaenoic acid in bladder cancer cells in vitro: alterations in mitoc...