| Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. | |
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MedLine Citation:
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PMID: 9989495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MALT B cell lymphomas with t(1;14)(p22;q32) showed a recurrent breakpoint upstream of the promoter of a novel gene, Bcl10. Bcl10 is a cellular homolog of the equine herpesvirus-2 E10 gene: both contain an amino-terminal caspase recruitment domain (CARD) homologous to that found in several apoptotic molecules. Bcl10 and E10 activated NF-kappaB but caused apoptosis of 293 cells. Bcl10 expressed in a MALT lymphoma exhibited a frameshift mutation resulting in truncation distal to the CARD. Truncated Bcl10 activated NF-kappaB but did not induce apoptosis. Wild-type Bcl10 suppressed transformation, whereas mutant forms had lost this activity and displayed gain-of-function transforming activity. Similar mutations were detected in other tumor types, indicating that Bcl10 may be commonly involved in the pathogenesis of human malignancy. |
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Authors:
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T G Willis; D M Jadayel; M Q Du; H Peng; A R Perry; M Abdul-Rauf; H Price; L Karran; O Majekodunmi; I Wlodarska; L Pan; T Crook; R Hamoudi; P G Isaacson; M J Dyer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell Volume: 96 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-03-16 Completed Date: 1999-03-16 Revised Date: 2008-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 35-45 Citation Subset: IM |
Affiliation:
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Academic Department of Haematology and Cytogenetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AJ006288; AJ006289; AJ006290; AJ006410 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing* Amino Acid Sequence Animals Apoptosis Base Sequence COS Cells Cell Line, Transformed Cell Transformation, Neoplastic Chromosomes, Human, Pair 1* Chromosomes, Human, Pair 14* Cloning, Molecular Gene Expression Hela Cells Humans Lymphoma, B-Cell, Marginal Zone / genetics* Mice Molecular Sequence Data Mutation* NF-kappa B / metabolism Neoplasm Proteins / genetics*, physiology Neoplasms / genetics Sequence Homology, Amino Acid Translocation, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/BCL10 protein, human; 0/Bcl10 protein, mouse; 0/NF-kappa B; 0/Neoplasm Proteins |
| Comments/Corrections | |
Comment In:
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Cell. 1999 Jun 11;97(6):683-4; discussion 686-8
[PMID:
10380920
]
Cell. 1999 Jun 11;97(6):684-6; discussion 686-8 [PMID: 10380921 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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