Document Detail


Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch.
MedLine Citation:
PMID:  22485198     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Cancer cells have developed novel mechanisms for evading chemotherapy-induced apoptosis and autophagy-associated cell death pathways. Upon the discovery that chemotherapeutics could target these cell death pathways in a manner that was not mutually exclusive, new discoveries about the interrelationship between these two pathways are emerging. Key proteins originally thought to be "autophagy-related proteins" are now found to be involved in either inducing or inhibiting apoptosis. Similarly, apoptosis inhibiting proteins can also block autophagy-associated cell death. One example is the complex formed by the autophagy protein, Beclin 1, and anti-apoptotic protein Bcl-2, which leads to inhibition of autophagy-associated cell death. Researchers have been investigating additional mechanisms that form/disrupt this complex in order to better design chemotherapeutics. This review will highlight the role Bcl-2 and Beclin 1 play in cancer development and drug resistance, as well as the role the Bcl-2:Beclin 1 complex in the switch between autophagy and apoptosis.
Authors:
Rebecca T Marquez; Liang Xu
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Publication Detail:
Type:  Journal Article     Date:  2012-02-15
Journal Detail:
Title:  American journal of cancer research     Volume:  2     ISSN:  2156-6976     ISO Abbreviation:  Am J Cancer Res     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-09     Completed Date:  2012-05-22     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  101549944     Medline TA:  Am J Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  214-21     Citation Subset:  -    
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