Document Detail


Bcl-2 family proteins: regulators of chemoresistance in cancer.
MedLine Citation:
PMID:  8597045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Knowledge about the mechanisms that regulate the expression of the family of BCL-2 genes and the biochemical characteristics of their encoded proteins is beginning to provide new insights into the origins of cancer and our all too often inability to adequately treat it. With better understanding of the functional significance of these protein-protein interactions involving Bcl-2, Bax, and other members of the Bcl-2 protein family and with insights into the structural details of these interactions, it may eventually be possible to develop novel pharmacological agents that improve tumor responses to currently available anticancer drugs and that have other clinically relevant uses as well.
Authors:
J C Reed
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Toxicology letters     Volume:  82-83     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-04-15     Completed Date:  1996-04-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Affiliation:
La Jolla Cancer Research Foundation, CA 92037, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Resistance
Gene Expression Regulation
Genes, p53
Humans
Neoplasms / drug therapy*
Proto-Oncogene Proteins / genetics,  physiology*
Proto-Oncogene Proteins c-bcl-2
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2

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