Document Detail


Bcl-2 expression in mycosis fungoides before and after PUVA therapy.
MedLine Citation:
PMID:  20415745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PUVA is the first therapeutic choice in early stages of mycosis fungoides (MF). In this study the effect of PUVA on bcl-2 expression in MF was assessed in 15 patients (three stage Ia and 12 stage Ib) and 10 controls. Two biopsies were taken from each patient before and after 24 sessions of PUVA therapy. Histopathological assessment and immunohistochemical staining for bcl-2 was performed and showed positive bcl-2 staining of lymphocytes in 53% of MF cases (8/15) before PUVA, with no statistically significant difference in the bcl-2 level before and after PUVA therapy (P value 0.3). A statistically significant difference was found in the bcl-2 level between control samples and MF patients' biopsies before (P value 0.02) and after PUVA therapy (P value 0.011). In conclusion, a lack of decline in the bcl-2 level and the absence of clinical or histopathological correlation with the bcl-2 level before and after PUVA therapy in MF patients suggest that PUVA-induced apoptosis in MF cases may occur through pathways other than bcl-2 inhibition.
Authors:
Hani Weshahy; Doa Mahgoub; Nermine El-Eishy; Amira Mohamed El-Tawdy; Dalia Ahmed Bassiouny; Nahla Hunter; Ali Hindawi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Photodermatology, photoimmunology & photomedicine     Volume:  26     ISSN:  1600-0781     ISO Abbreviation:  Photodermatol Photoimmunol Photomed     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013641     Medline TA:  Photodermatol Photoimmunol Photomed     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  107-9     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Kasr El-Aini University Hospital, Cairo University, Cairo, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Adult
Apoptosis* / drug effects,  radiation effects
Female
Gene Expression Regulation, Neoplastic* / drug effects,  radiation effects
Humans
Lymphocytes / pathology
Male
Middle Aged
Mycosis Fungoides / drug therapy,  metabolism*,  pathology
PUVA Therapy*
Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
Skin Neoplasms / drug therapy,  metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-bcl-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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