| Bcl-2 expression in mycosis fungoides before and after PUVA therapy. | |
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MedLine Citation:
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PMID: 20415745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PUVA is the first therapeutic choice in early stages of mycosis fungoides (MF). In this study the effect of PUVA on bcl-2 expression in MF was assessed in 15 patients (three stage Ia and 12 stage Ib) and 10 controls. Two biopsies were taken from each patient before and after 24 sessions of PUVA therapy. Histopathological assessment and immunohistochemical staining for bcl-2 was performed and showed positive bcl-2 staining of lymphocytes in 53% of MF cases (8/15) before PUVA, with no statistically significant difference in the bcl-2 level before and after PUVA therapy (P value 0.3). A statistically significant difference was found in the bcl-2 level between control samples and MF patients' biopsies before (P value 0.02) and after PUVA therapy (P value 0.011). In conclusion, a lack of decline in the bcl-2 level and the absence of clinical or histopathological correlation with the bcl-2 level before and after PUVA therapy in MF patients suggest that PUVA-induced apoptosis in MF cases may occur through pathways other than bcl-2 inhibition. |
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Authors:
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Hani Weshahy; Doa Mahgoub; Nermine El-Eishy; Amira Mohamed El-Tawdy; Dalia Ahmed Bassiouny; Nahla Hunter; Ali Hindawi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Photodermatology, photoimmunology & photomedicine Volume: 26 ISSN: 1600-0781 ISO Abbreviation: Photodermatol Photoimmunol Photomed Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-07-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013641 Medline TA: Photodermatol Photoimmunol Photomed Country: Denmark |
Other Details:
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Languages: eng Pagination: 107-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Kasr El-Aini University Hospital, Cairo University, Cairo, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apoptosis* / drug effects, radiation effects Female Gene Expression Regulation, Neoplastic* / drug effects, radiation effects Humans Lymphocytes / pathology Male Middle Aged Mycosis Fungoides / drug therapy, metabolism*, pathology PUVA Therapy* Proto-Oncogene Proteins c-bcl-2 / biosynthesis* Skin Neoplasms / drug therapy, metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-bcl-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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