| Bcl-2: an antidote to programmed cell death. | |
| | |
MedLine Citation:
|
PMID: 1451107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The maintenance of homoeostasis in normal tissues reflects a balance between cell proliferation and cell death. The importance of both positive and negative regulators of cell growth has been well documented in neoplasia. bcl-2 argues for the existence of a new category of oncogenes, regulators of programmed cell death. The bcl-2 gene was identified at the chromosomal breakpoint of t(14;18) bearing B cell lymphomas. Bcl-2 has proved to be unique among proto-oncogenes in being localized to mitochondria and in blocking programmed cell death rather than affecting proliferation. In adults, bcl-2 is topographically restricted to progenitor cells and long-lived cells in tissues characterized by apoptotic cell death. Bcl-2 is confined to the zones of surviving B cells in germinal centres. Within thymus, bcl-2 is present in the surviving mature thymocytes of the medulla but absent from the majority of immature cortical thymocytes, most of which die by apoptosis. Transgenic mice that overexpress bcl-2 in the B cell lineage demonstrate extended cell survival and prolonged immune responses and indicate a role for bcl-2 in B cell memory. Transgenic models that overexpress bcl-2 in the thymus have expanded the involvement of bcl-2 to multiple apoptotic pathways and indicate its involvement in thymocyte maturation. Moreover, the development of tumours in transgenic mice that overexpress bcl-2 indicates the potential importance of oncogenes in interfering with programmed cell death. Alterations in genes that regulate cell death may prove to be key events in neoplasia, extending the life span of cells and thus increasing their opportunity to acquire additional genetic aberrations. |
| | |
Authors:
|
S J Korsmeyer |
Related Documents
:
|
10869957 - Fibronectin influences cellular proliferation and apoptosis similarly in lncap and pc-3... 9303307 - The anti-apoptosis function of bcl-2 can be genetically separated from its inhibitory e... 17705137 - Bim regulates bcr-induced entry of b cells into the cell cycle. 19246337 - Abt-737 synergizes with chemotherapy to kill head and neck squamous cell carcinoma cell... 3874697 - Free cytosolic ca2+ measurements with fluorine labelled indicators using 19fnmr. 11385617 - Kir down-regulation on nk cells is associated with down-regulation of activating recept... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Cancer surveys Volume: 15 ISSN: 0261-2429 ISO Abbreviation: Cancer Surv. Publication Date: 1992 |
Date Detail:
|
Created Date: 1993-01-06 Completed Date: 1993-01-06 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 8218015 Medline TA: Cancer Surv Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 105-18 Citation Subset: IM |
Affiliation:
|
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
B-Lymphocytes
/
pathology Cell Death Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 18 GTP-Binding Proteins / genetics Humans Lymphoma, Follicular / genetics*, pathology* Oncogenes / genetics* Protein-Tyrosine Kinases / genetics Proto-Oncogene Proteins / genetics Proto-Oncogene Proteins c-bcl-2 |
| Chemical | |
Reg. No./Substance:
|
0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 3.6.1.-/GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Species and sex differences of aflatoxin B1-induced glutathione S-transferase placental form in sing...
Next Document: Oncogene co-operation in leukaemogenesis.