Document Detail

Bcl-2 accelerates the neuronal differentiation: new evidence approaching to the biofunction of bcl-2 in the neuronal system.
MedLine Citation:
PMID:  9729279     Owner:  NLM     Status:  MEDLINE    
The proto-oncogene product Bcl-2 is unique in that it inhibits apoptosis rather than promoting cell proliferation. In the present study, we encountered a new possible role of Bcl-2 in the neuronal differentiation. Rat pheochromocytoma PC12 cells have been known as the model of neuronal differentiation by the stimulation of NGF. Bcl-2 transfected PC12 (MB2) cells showed the accelerated neuronal differentiation, as compared with control PC12 (V4) cells. In addition, chemotherapeutic agents Taxol which has been known as neurotoxic compound, induced the acute neuronal cell atrophy and suppressed neuronal differentiation. This neuronal cell atrophy and suppression of neuronal differentiation were not due to apoptotic cell death. Interestingly, Bcl-2 rescued PC12 cells from both neuronal cell atrophy and suppression of neuronal differentiation. Taxol suppressed polymerization between neurofilament light and heavy (NF-L and NF-H), and MB2 cell extract rescued it. We, therefore, suggest the acceleration of polymerization between NF-L and NF-H as the new possible role of Bcl-2.
A Suzuki; Y Tsutomi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  801     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1999-05-12     Completed Date:  1999-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Elsevier Science B.V.
Drug Safety Research Laboratory, Daiichi Pharmaceutical Co. Ltd., Tokyo R&D Center 16-13, Kiatakasai-1, Edogawa-ku, Tokyo 134, Japan.
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MeSH Terms
Biopolymers / metabolism
Cell Differentiation / drug effects
Models, Biological
Nerve Growth Factors / antagonists & inhibitors,  pharmacology
Neurofilament Proteins / drug effects,  metabolism
Neurons / cytology*,  drug effects
PC12 Cells
Paclitaxel / pharmacology
Proto-Oncogene Proteins c-bcl-2 / genetics,  physiology*
Stem Cells / cytology,  drug effects
Reg. No./Substance:
0/Biopolymers; 0/Nerve Growth Factors; 0/Neurofilament Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/neurofilament protein L; 33069-62-4/Paclitaxel

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