Document Detail


Bcl-2 accelerates the neuronal differentiation: new evidence approaching to the biofunction of bcl-2 in the neuronal system.
MedLine Citation:
PMID:  9729279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The proto-oncogene product Bcl-2 is unique in that it inhibits apoptosis rather than promoting cell proliferation. In the present study, we encountered a new possible role of Bcl-2 in the neuronal differentiation. Rat pheochromocytoma PC12 cells have been known as the model of neuronal differentiation by the stimulation of NGF. Bcl-2 transfected PC12 (MB2) cells showed the accelerated neuronal differentiation, as compared with control PC12 (V4) cells. In addition, chemotherapeutic agents Taxol which has been known as neurotoxic compound, induced the acute neuronal cell atrophy and suppressed neuronal differentiation. This neuronal cell atrophy and suppression of neuronal differentiation were not due to apoptotic cell death. Interestingly, Bcl-2 rescued PC12 cells from both neuronal cell atrophy and suppression of neuronal differentiation. Taxol suppressed polymerization between neurofilament light and heavy (NF-L and NF-H), and MB2 cell extract rescued it. We, therefore, suggest the acceleration of polymerization between NF-L and NF-H as the new possible role of Bcl-2.
Authors:
A Suzuki; Y Tsutomi
Related Documents :
19754129 - Inactivation of epidermal growth factor receptor and downstream pathways in oral squamo...
19232459 - Long duration exposure to cadmium leads to increased cell survival, decreased dna repai...
11246129 - Association between bcl-x(l) and 5-lipoxygenase activating protein (flap) levels in il-...
11376499 - Differential expression of cd95, bcl-2, and bax in rat gastric chief and parietal cells.
1633729 - Flow cytometric detection of the mitochondrial bcl-2 protein in normal and neoplastic h...
12057719 - Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endome...
8772619 - Diabetes mellitus and impaired pancreatic beta-cell proliferation.
19318679 - Characterization of primary cilia in human airway smooth muscle cells.
24653569 - Evaluation of royal jelly as an alternative to fetal bovine serum in cell culture using...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  801     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1999-05-12     Completed Date:  1999-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Elsevier Science B.V.
Affiliation:
Drug Safety Research Laboratory, Daiichi Pharmaceutical Co. Ltd., Tokyo R&D Center 16-13, Kiatakasai-1, Edogawa-ku, Tokyo 134, Japan. LEBOO373@niftyserve.or.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biopolymers / metabolism
Cell Differentiation / drug effects
Humans
Models, Biological
Nerve Growth Factors / antagonists & inhibitors,  pharmacology
Neurofilament Proteins / drug effects,  metabolism
Neurons / cytology*,  drug effects
PC12 Cells
Paclitaxel / pharmacology
Proto-Oncogene Proteins c-bcl-2 / genetics,  physiology*
Rats
Stem Cells / cytology,  drug effects
Transfection
Chemical
Reg. No./Substance:
0/Biopolymers; 0/Nerve Growth Factors; 0/Neurofilament Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/neurofilament protein L; 33069-62-4/Paclitaxel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depr...
Next Document:  Re-epithelialization of the rabbit cornea is regulated by opioid growth factor.