Document Detail

Bayesian network meta-analysis of root coverage procedures: ranking efficacy and identification of best treatment.
MedLine Citation:
PMID:  23346965     Owner:  NLM     Status:  MEDLINE    
AIMS: The aim of this work was to conduct a Bayesian network meta-analysis (NM) of randomized controlled trials (RCTs) to establish a ranking in efficacy and the best technique for coronally advanced flap (CAF)-based root coverage procedures.
MATERIAL AND METHODS: A literature search on PubMed, Cochrane libraries, EMBASE, and hand-searched journals until June 2012 was conducted to identify RCTs on treatments of Miller Class I and II gingival recessions with at least 6 months of follow-up. The treatment outcomes were recession reduction (RecRed), clinical attachment gain (CALgain), keratinized tissue gain (KTgain), and complete root coverage (CRC).
RESULTS: Twenty-nine studies met the inclusion criteria, 20 of which were classified as at high risk of bias. The CAF+connective tissue graft (CTG) combination ranked highest in effectiveness for RecRed (Probability of being the best = 40%) and CALgain (Pr = 33%); CAF+enamel matrix derivative (EMD) was slightly better for CRC; CAF+Collagen Matrix (CM) appeared effective for KTgain (Pr = 69%). Network inconsistency was low for all outcomes excluding CALgain.
CONCLUSION: CAF+CTG might be considered the gold standard in root coverage procedures. The low amount of inconsistency gives support to the reliability of the present findings.
Jacopo Buti; Michela Baccini; Michele Nieri; Michele La Marca; Giovan P Pini-Prato
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; Validation Studies     Date:  2013-01-24
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  40     ISSN:  1600-051X     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-09-11     Revised Date:  2014-01-02    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  372-86     Citation Subset:  D; IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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MeSH Terms
Bayes Theorem
Collagen / therapeutic use
Connective Tissue / transplantation*
Dental Enamel Proteins / therapeutic use
Gingival Recession / surgery*
Information Storage and Retrieval / methods
Monte Carlo Method
Periodontal Attachment Loss / surgery
Randomized Controlled Trials as Topic*
Reproducibility of Results
Surgical Flaps
Treatment Outcome
Reg. No./Substance:
0/Dental Enamel Proteins; 0/enamel matrix proteins; 9007-34-5/Collagen
Comment In:
J Evid Based Dent Pract. 2013 Dec;13(4):157-9   [PMID:  24237738 ]

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