Document Detail


Bayesian methods for estimating pathogen prevalence within groups of animals from faecal-pat sampling.
MedLine Citation:
PMID:  12706055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pathogens such as Escherichia coli O157:H7 and Campylobacter spp. have been implicated in outbreaks of food poisoning in the UK and elsewhere. Domestic animals and wildlife are important reservoirs for both of these agents, and cross-contamination from faeces is believed to be responsible for many human outbreaks. Appropriate parameterisation of quantitative microbial-risk models requires representative data at all levels of the food chain. Our focus in this paper is on the early stages of the food chain-specifically, sampling issues which arise at the farm level. We estimated animal-pathogen prevalence from faecal-pat samples using a Bayesian method which reflected the uncertainties inherent in the animal-level prevalence estimates. (Note that prevalence here refers to the percentage of animals shedding the bacteria of interest). The method offers more flexibility than traditional, classical approaches: it allows the incorporation of prior belief, and permits the computation of a variety of distributional and numerical summaries, analogues of which often are not available through a classical framework. The Bayesian technique is illustrated with a number of examples reflecting the effects of a diversity of assumptions about the underlying processes. The technique appears to be both robust and flexible, and is useful when defecation rates in infected and uninfected groups are unequal, where population size is uncertain, and also where the microbiological-test sensitivity is imperfect. We also investigated the determination of the sample size necessary for determining animal-level prevalence from pat samples to within a pre-specified degree of accuracy.
Authors:
H E Clough; D Clancy; P D O'Neill; N P French
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Preventive veterinary medicine     Volume:  58     ISSN:  0167-5877     ISO Abbreviation:  Prev. Vet. Med.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-22     Completed Date:  2003-09-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8217463     Medline TA:  Prev Vet Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  145-69     Citation Subset:  IM    
Affiliation:
Department of Veterinary Clinical Sciences, University of Liverpool, Leahurst, Neston, CH64 7TE, South Wirral, UK. h.e.clough@liv.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Agriculture
Animal Diseases / epidemiology*,  microbiology*,  transmission
Animals
Bayes Theorem*
Campylobacter Infections / epidemiology,  transmission
Cattle
Escherichia coli Infections / epidemiology,  transmission
Escherichia coli O157 / isolation & purification
Feces / microbiology*
Foodborne Diseases / microbiology
Models, Statistical*
Prevalence
Zoonoses / microbiology,  transmission
Comments/Corrections
Erratum In:
Prev Vet Med. 2003 Aug 8;60(2):193

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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