| Bax-deficient mice with lymphoid hyperplasia and male germ cell death. | |
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MedLine Citation:
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PMID: 7569956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BAX, a heterodimeric partner of BCL2, counters BCL2 and promotes apoptosis in gain-of-function experiments. A Bax knockout mouse was generated that proved viable but displayed lineage-specific aberrations in cell death. Thymocytes and B cells in this mouse displayed hyperplasia, and Bax-deficient ovaries contained unusual atretic follicles with excess granulosa cells. In contrast, Bax-deficient males were infertile as a result of disordered seminiferous tubules with an accumulation of atypical premeiotic germ cells, but no mature haploid sperm. Multinucleated giant cells and dysplastic cells accompanied massive cell death. Thus, the loss of Bax results in hyperplasia or hypoplasia, depending on the cellular context. |
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Authors:
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C M Knudson; K S Tung; W G Tourtellotte; G A Brown; S J Korsmeyer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 270 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-11-07 Completed Date: 1995-11-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 96-9 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis B-Lymphocytes / cytology Female Granulosa Cells / cytology Hyperplasia / pathology Infertility, Male / pathology* Lymphoid Tissue / pathology* Male Mice Mice, Knockout Ovary / cytology Proto-Oncogene Proteins / deficiency*, genetics, physiology Proto-Oncogene Proteins c-bcl-2* Seminiferous Tubules / pathology* Spermatids / pathology Spermatocytes / ultrastructure Spermatogenesis Spermatozoa / pathology* T-Lymphocytes / cytology bcl-2-Associated X Protein |
| Grant Support | |
ID/Acronym/Agency:
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CA49712/CA/NCI NIH HHS; HD27500/HD/NICHD NIH HHS; P30-HD28934/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bax protein, mouse; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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