Document Detail


Bax-deficient mice with lymphoid hyperplasia and male germ cell death.
MedLine Citation:
PMID:  7569956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BAX, a heterodimeric partner of BCL2, counters BCL2 and promotes apoptosis in gain-of-function experiments. A Bax knockout mouse was generated that proved viable but displayed lineage-specific aberrations in cell death. Thymocytes and B cells in this mouse displayed hyperplasia, and Bax-deficient ovaries contained unusual atretic follicles with excess granulosa cells. In contrast, Bax-deficient males were infertile as a result of disordered seminiferous tubules with an accumulation of atypical premeiotic germ cells, but no mature haploid sperm. Multinucleated giant cells and dysplastic cells accompanied massive cell death. Thus, the loss of Bax results in hyperplasia or hypoplasia, depending on the cellular context.
Authors:
C M Knudson; K S Tung; W G Tourtellotte; G A Brown; S J Korsmeyer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  270     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-07     Completed Date:  1995-11-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  96-9     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
B-Lymphocytes / cytology
Female
Granulosa Cells / cytology
Hyperplasia / pathology
Infertility, Male / pathology*
Lymphoid Tissue / pathology*
Male
Mice
Mice, Knockout
Ovary / cytology
Proto-Oncogene Proteins / deficiency*,  genetics,  physiology
Proto-Oncogene Proteins c-bcl-2*
Seminiferous Tubules / pathology*
Spermatids / pathology
Spermatocytes / ultrastructure
Spermatogenesis
Spermatozoa / pathology*
T-Lymphocytes / cytology
bcl-2-Associated X Protein
Grant Support
ID/Acronym/Agency:
CA49712/CA/NCI NIH HHS; HD27500/HD/NICHD NIH HHS; P30-HD28934/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Bax protein, mouse; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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