Document Detail


Basosquamous carcinoma: analysis of prognostic factors influencing recurrence.
MedLine Citation:
PMID:  10717618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Basosquamous carcinoma is a rare malignancy, with features of both basal cell carcinoma and squamous cell carcinoma. Some authors believe that basosquamous carcinoma merely is a variant of basal cell carcinoma, whereas others have suggested that basosquamous carcinoma may behave more aggressively. To the authors' knowledge the largest published series to date, comprised of 35 cases, was reported >20 years ago. The authors reviewed their recent experience with basosquamous carcinoma to identify prognostic factors influencing recurrence. METHODS: The medical records of all patients with the diagnosis of basosquamous carcinoma treated at the University of Louisville-affiliated hospitals between 1985-1988 were reviewed by a senior pathologist. Prognostic factors were analyzed using Cox regression analysis and the log rank test. RESULTS: Thirty-one cases of basosquamous carcinoma were identified in 28 patients. The median age at diagnosis was 68 years (range, 10-94 years). The median follow-up was 60 months (range, 12-312 months). Seventy-five percent of cases were located on the face, neck, and scalp. One patient had regional lymph node metastasis synchronous with the primary tumor. Patterns of recurrence were: local recurrence only (five patients), local recurrence plus regional lymph nodes (three patients), and pulmonary plus regional lymph nodes (one patient). One patient died of pulmonary metastasis. Significant factors predictive of recurrence (P<0.01) were male gender, positive surgical resection margin, lymphatic invasion, and perineural invasion. Although tumor size was not a statistically significant factor overall (P = 0.076), the 3 patients with lymph node metastases had large tumors (measuring 2 cm, 5 cm, and 5 cm, respectively). CONCLUSIONS: Basosquamous carcinoma is an aggressive epithelial neoplasm with a propensity for local recurrence and potential for distant metastatic spread. This behavior differs substantially from basal cell carcinoma. Complete resection with negative surgical margins is essential. Long term follow-up for the detection of local recurrence and distant metastatic spread is recommended.
Authors:
R C Martin; M J Edwards; T G Cawte; C L Sewell; K M McMasters
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  88     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-27     Completed Date:  2000-04-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1365-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2000 American Cancer Society.
Affiliation:
Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Carcinoma, Basosquamous / pathology*,  secondary,  surgery
Child
Facial Neoplasms / pathology
Female
Follow-Up Studies
Head and Neck Neoplasms / pathology
Humans
Linear Models
Lung Neoplasms / pathology,  secondary
Lymphatic Metastasis / pathology
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local / pathology
Neoplasm, Residual
Prognosis
Proportional Hazards Models
Retrospective Studies
Scalp / pathology
Sex Factors
Skin Neoplasms / pathology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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