Document Detail

Basophil count in neonates is not suitable for atopy predictivity.
MedLine Citation:
PMID:  9015783     Owner:  NLM     Status:  MEDLINE    
Basophil granulocytes and their mediators are involved in the pathogenesis of allergic inflammation. We evaluated basophil count, blood histamine content, eosinophil count and serum total IgE levels in one hundred-thirteen healthy newborns at birth. 102 children were prospectively studied with a follow up to 18 months of age for development of atopic disorders. No difference was found in newborns with biparental family history of atopy (FHA) in comparison with newborns with monoparental FHA and with newborns without FHA. Children who developed atopic disorders had neonatal basophil counts higher than those who did not develop atopic symptoms (p = 0.03). No significant correlation was found between basophil and eosinophil counts (rs = 0.013), between basophil count and serum total IgE levels (rs = 0.012) and between basophil count and blood histamine content. Positive predictive value and sensitivity of basophil count for allergy up to 18 months of age was only 33% and 27%, respectively. Our data indicate that an increased basophil count at birth is not associated with FHA and is not a good predictive marker of atopy.
M Calbi; L Giacchetti; A Coppola; M Triggiani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigational allergology & clinical immunology     Volume:  6     ISSN:  1018-9068     ISO Abbreviation:  J Investig Allergol Clin Immunol     Publication Date:    1996 Nov-Dec
Date Detail:
Created Date:  1997-04-09     Completed Date:  1997-04-09     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  9107858     Medline TA:  J Investig Allergol Clin Immunol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  383-7     Citation Subset:  IM    
Department of Pediatrics, Villa Bianca Hospital, Naples, Italy.
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MeSH Terms
Hypersensitivity, Immediate / blood*,  diagnosis*
Infant, Newborn
Leukocyte Count
Predictive Value of Tests

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