| Basophil count in neonates is not suitable for atopy predictivity. | |
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MedLine Citation:
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PMID: 9015783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Basophil granulocytes and their mediators are involved in the pathogenesis of allergic inflammation. We evaluated basophil count, blood histamine content, eosinophil count and serum total IgE levels in one hundred-thirteen healthy newborns at birth. 102 children were prospectively studied with a follow up to 18 months of age for development of atopic disorders. No difference was found in newborns with biparental family history of atopy (FHA) in comparison with newborns with monoparental FHA and with newborns without FHA. Children who developed atopic disorders had neonatal basophil counts higher than those who did not develop atopic symptoms (p = 0.03). No significant correlation was found between basophil and eosinophil counts (rs = 0.013), between basophil count and serum total IgE levels (rs = 0.012) and between basophil count and blood histamine content. Positive predictive value and sensitivity of basophil count for allergy up to 18 months of age was only 33% and 27%, respectively. Our data indicate that an increased basophil count at birth is not associated with FHA and is not a good predictive marker of atopy. |
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Authors:
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M Calbi; L Giacchetti; A Coppola; M Triggiani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología Volume: 6 ISSN: 1018-9068 ISO Abbreviation: J Investig Allergol Clin Immunol Publication Date: 1996 Nov-Dec |
Date Detail:
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Created Date: 1997-04-09 Completed Date: 1997-04-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9107858 Medline TA: J Investig Allergol Clin Immunol Country: SPAIN |
Other Details:
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Languages: eng Pagination: 383-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Villa Bianca Hospital, Naples, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Basophils* Humans Hypersensitivity, Immediate / blood*, diagnosis* Infant, Newborn Leukocyte Count Predictive Value of Tests |
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