| The Basis of Differential Responses to Folic Acid Supplementation. | |
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MedLine Citation:
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PMID: 21625172 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background/Aims: Elevated levels of total homocysteine (tHcy) are associated with an increased risk of many common diseases. Supplementation with folic acid has been shown to significantly reduce tHcy levels. We used the classical twin model to partition the variability in changes in plasma tHcy levels through folic acid supplementation into genetic, environmental, and confounding epidemiological factors. Methods: We carried out an intervention study of folic acid using 101 healthy, female, identical and non-identical twins aged 50-80 years. Each twin was administered folic acid (0.8 mg/day) for 6 weeks. Total plasma folate, cobalamin and tHcy were measured at both baseline and after dosing. We calculated the heritability and tested for associations between the MTHFR C677T functional variant and response to folic acid supplementation. Results: Supplementation with folic acid led to a significant reduction in tHcy levels. The mean tHcy changed from 12.14 to 10.42 μmol/l after supplementation (p < 10(-5)). Moreover, the change in tHcy levels was highly heritable (64%), not associated with the C677T functional variant at MTHFR and not confounded by age, BMI or diet. Conclusions: Our results highlight the need to identify genetic factors associated with biomarkers of response to folate supplementation. |
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Authors:
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Ioana Cotlarciuc; Toby Andrew; Tracy Dew; Gail Clement; Raj Gill; Gabriela Surdulescu; Roy Sherwood; Kourosh R Ahmadi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-28 |
Journal Detail:
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Title: Journal of nutrigenetics and nutrigenomics Volume: 4 ISSN: 1661-6758 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101299758 Medline TA: J Nutrigenet Nutrigenomics Country: - |
Other Details:
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Languages: ENG Pagination: 99-109 Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Department of Twin Research and Genetic Epidemiology, King's College Hospital, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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