| Basilar artery occlusion in rats. | |
| | |
MedLine Citation:
|
PMID: 2003289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The basilar artery is one of the three major sources of blood supply to the circle of Willis. To investigate the effects of basilar artery occlusion, we surgically exposed and coagulated the basilar artery in 25 rats. Basilar artery occlusion at any single point between the foramen magnum and the circle of Willis in 11 rats did not produce histologically detectable infarcts in the brain at 12-24 hours. Two-point occlusions of the basilar artery in 12 rats produced variable infarcts between the occlusion sites but no ischemic lesions elsewhere. After either single- or double-point occlusions, the proximal basilar artery refilled within 2-3 minutes. When the basilar artery was occluded above and below the origins of the anterior inferior cerebellar arteries, the artery segments between the occlusion points initially collapsed but refilled within 2-3 minutes in two rats. Basilar artery occlusions invariably suppressed cortical somatosensory evoked potentials by greater than 50%. Regardless of whether a brain stem infarct developed, somatosensory evoked potential amplitudes recovered to greater than baseline levels by 4 hours in seven of 17 rats and returned to baseline levels by 24 hours in every rat tested. We conclude that the occluded basilar artery receives extensive retrograde collateral blood flow and that somatosensory evoked potentials are exquisitely sensitive to basilar artery occlusion but are insensitive to whether brain stem infarcts develop. |
| | |
Authors:
|
J C Wojak; V DeCrescito; W Young |
Related Documents
:
|
2067589 - Release of endogenous catecholamines in two different regions of the nucleus of the sol... 12197469 - Arteriogenesis, a new concept of vascular adaptation in occlusive disease. 11173339 - Hypotension after coronary arterial occlusion induces regional expression of c-fos prot... 20853359 - Retrograde approach to recanalization of complex tibial disease. 15517229 - Influence of the site of arterial occlusion on multiple baseline hemodynamic mri parame... 3339439 - Use of etomidate, temporary arterial occlusion, and intraoperative angiography in surgi... 6251409 - Case report: false aneurysm due to synovial sarcoma. 12124969 - Patterns of late diameter change after balloon angioplasty of branch pulmonary artery s... 9123639 - Diagnosis and follow-up of carotid-cavernous fistulas by carotid duplex sonography and ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: 22 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1991 Feb |
Date Detail:
|
Created Date: 1991-04-18 Completed Date: 1991-04-18 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 247-52 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, New York University School of Medicine, New York. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arterial Occlusive Diseases* / complications, pathology, physiopathology Basilar Artery* Blood Pressure Brain / pathology Cerebral Infarction / etiology Cerebrovascular Circulation Evoked Potentials, Somatosensory Rats Rats, Inbred Strains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clentiazem reduces infarct size in rabbit middle cerebral artery occlusion.
Next Document: Detection of arterial emboli using Doppler ultrasound in rabbits.