| Basic mechanisms of tendon fatigue damage. | |
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MedLine Citation:
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PMID: 22244058 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Pathologic processes intrinsic and extrinsic to the tendons have been proposed as the underlying cause of rotator cuff disease, but the precise etiology is not known. Tear formation is, in part, attributable to the accumulation of subrupture tendon fatigue damage. We review the molecular, mechanical, and structural changes induced in tendons subjected to controlled amounts of fatigue loading in an animal model of early tendinopathy. The distinct tendon responses to low and moderate levels of loading, as opposed to high levels, provide insight into the potential mechanisms for the therapeutic benefits of exercise in the treatment of rotator cuff tendinopathy. The progression of damage accumulation leading to fiber rupture and eventual tendon tearing seen with higher loading illustrates the progression from tendinopathy to full-thickness tearing. We hope that this more realistic animal model of tendon fatigue damage will allow better assessment of biologic, mechanical, tissue-engineering, and rehabilitation strategies to improve repair success. |
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Authors:
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Andrew Neviaser; Nelly Andarawis-Puri; Evan Flatow |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.] Volume: 21 ISSN: 1532-6500 ISO Abbreviation: J Shoulder Elbow Surg Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206499 Medline TA: J Shoulder Elbow Surg Country: United States |
Other Details:
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Languages: eng Pagination: 158-63 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Orthopaedic Surgery, Mount Sinai School of Medicine, New York, NY, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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