Document Detail


Basic functional properties of the cardiac muscle of the common shrew (Sorex araneus) and some other small mammals.
MedLine Citation:
PMID:  2809495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The resting heartbeat frequency of all the studied wild small mammals (body mass 3-20 g) was lower than that predicted by the allometric equation for a typical mammal. The heart rate of the laboratory mouse was a little higher than the expected value. The ventricular mass of the small wild mammals was higher than predicted for their size, but that of the laboratory mouse was below the expected value. Thus, adequate cardiac output in the wild small mammals is achieved by compensating the low heartbeat frequency with greater stroke volume. The shrew species are notable exceptions, which, despite having a metabolic rate 2-3 times higher than the mammalian average, neither have exceptionally high heart rates nor larger hearts than other wild small mammals. The adaptation of the shrew heart to high metabolic rate may reside in the shape of heart. The ventricular myocardium of shrews is characteristically long and narrow with a tapered apex, whereas other small mammals have rounder hearts. The duration of the ventricular action potential was short and inversely proportional to the resting heart rate of the mammalian species. Caffeine (5 mmol l-1) strongly decreased the isometric contractile force of right ventricular strips in all the studied mammals. These findings suggest that in the small mammals intracellular stores are the main source of activating Ca2+, whereas transsarcolemmal Ca2+ movement may only serve the triggering function.
Authors:
M Vornanen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  145     ISSN:  0022-0949     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-12-01     Completed Date:  1989-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  339-51     Citation Subset:  IM    
Affiliation:
Department of Biology, University of Joensuu, Finland.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Caffeine / pharmacokinetics
Electrocardiography
Heart / anatomy & histology,  physiology*
Heart Rate
Mice
Mice, Inbred Strains
Organ Size
Rats
Rats, Inbred Strains
Shrews / physiology*
Chemical
Reg. No./Substance:
58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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