Document Detail


Basic fibroblast growth factor increases collateral blood flow in rats with femoral arterial ligation.
MedLine Citation:
PMID:  8925570     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potential for exogenous infusion of basic fibroblast growth factor (bFGF) to increase collateral blood flow to dependent tissue was quantified in adult male rats with peripheral arterial insufficiency. Occlusion of the femoral artery at a proximal site did not infringe on resting blood flow to the distal hindlimb muscle, but did remove the blood flow reserve. Blood flow to the hindlimb muscles was measured with radiolabeled microspheres using an isolated hindlimb preparation perfused in the descending aorta (Krebs-Henseleit bicarbonate, 5% albumin medium containing red blood cells [40% hematocrit]) at 100 mm Hg. Calf muscle blood flow changed modestly (approximately equal to 50%) with infusion of only the carrier (heparin/saline), increased markedly over the first 2 weeks of bFGF infusion (1 microgram/d into the femoral artery), but did not change further with infusion for 4 weeks. Waiting 2 weeks after 1 week of bFGF infusion did not further increase the intermediate improvement in blood flow. The improved collateral blood flow and increased muscle capillary density likely contributed to the enhanced muscle performance observed during nerve stimulation in situ. X-ray films of arterial casts identified an expansion of upper thigh vessels that likely served as collaterals. In animals with peripheral arterial insufficiency, short-term exogenous infusion of bFGF is effective at inducing vascular expansion that is sufficient to improve the flow reserve of dependent distal tissue and enhance muscle function. This raises the expectation that a similar response in patients with peripheral arterial insufficiency would significantly improve morbidity, including the symptoms of intermittent claudication.
Authors:
H T Yang; M R Deschenes; R W Ogilvie; R L Terjung
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  79     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-11-12     Completed Date:  1996-11-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  62-9     Citation Subset:  IM    
Affiliation:
Department of Physiology, State University of New York, Health Science Center at Syracuse 13210, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Capillaries
Collateral Circulation / drug effects*
Femoral Artery / physiology*
Fibroblast Growth Factor 2 / pharmacology*
Hindlimb / blood supply,  radiography
Ligation
Male
Muscle Contraction
Muscles / blood supply,  drug effects,  physiology
Perfusion
Rats
Rats, Sprague-Dawley
Regional Blood Flow / drug effects
Grant Support
ID/Acronym/Agency:
HL-37387/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
103107-01-3/Fibroblast Growth Factor 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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