Document Detail

Basic concepts about genes, inactivity and aging.
MedLine Citation:
PMID:  19602189     Owner:  NLM     Status:  MEDLINE    
Remarkably, 80-year-old humans who have partaken in lifelong aerobic or strength training have maximal aerobic capacities or muscle strengths comparable with that of sedentary individuals aged 50 or 55-year-old, respectively. Such delays in functional aging are clinically significant because lower aerobic and lower strength capacities increase the risk of premature death. In this short review, we speculate that the lack of daily physical activity induces evolutionarily selected mechanisms to use or lose, one of which is related to nutritional status.
F W Booth; K A Zwetsloot
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2009-07-03
Journal Detail:
Title:  Scandinavian journal of medicine & science in sports     Volume:  20     ISSN:  1600-0838     ISO Abbreviation:  Scand J Med Sci Sports     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111504     Medline TA:  Scand J Med Sci Sports     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Health Activity Center, Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA.
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MeSH Terms
Aging / physiology*
Exercise / physiology*
Gluconeogenesis / physiology
Muscle Strength / physiology
Muscle, Skeletal / physiopathology
Muscular Atrophy / physiopathology
Oxygen Consumption / physiology
Resistance Training
Running / physiology
Sarcopenia / physiopathology
Grant Support

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