| Basic clinical and laboratory features of filoviral hemorrhagic Fever. | |
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MedLine Citation:
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PMID: 21987756 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The filoviruses Marburg and Ebola cause severe hemorrhagic fever (HF) in humans. Beginning with the 1967 Marburg outbreak, 30 epidemics, isolated cases, and accidental laboratory infections have been described in the medical literature. We reviewed those reports to determine the basic clinical and laboratory features of filoviral HF. The most detailed information was found in descriptions of patients treated in industrialized countries; except for the 2000 outbreak of Ebola Sudan HF in Uganda, reports of epidemics in central Africa provided little controlled or objective clinical data. Other than the case fatality rate, there were no clear differences in the features of the various filovirus infections. This compilation will be of value to medical workers responding to epidemics and to investigators attempting to develop animal models of filoviral HF. By identifying key unanswered questions and gaps in clinical data, it will help guide clinical research in future outbreaks. |
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Authors:
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Mark G Kortepeter; Daniel G Bausch; Mike Bray |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 204 Suppl 3 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: S810-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Preventive Medicine, Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda Maryland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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