Document Detail

Basic and clinical aspects of non-neuronal acetylcholine: overview of non-neuronal cholinergic systems and their biological significance.
MedLine Citation:
PMID:  18285657     Owner:  NLM     Status:  MEDLINE    
Acetylcholine (ACh) is a phylogenetically ancient molecule involved in cell-to-cell signaling in almost all life-forms on earth. Cholinergic components, including ACh, choline acetyltransferase, acetylcholinesterase, and muscarinic and nicotinic ACh receptors (mAChRs and nAChRs, respectively) have been identified in numerous non-neuronal cells and tissues, including keratinocytes, cancer cells, immune cells, urinary bladder, airway epithelial cells, vascular endothelial cells, and reproductive organs, among many others. Stimulation of the mAChRs and nAChRs elicits cell-specific functional and biochemical effects. These findings support the notion that non-neuronal cholinergic systems are expressed in certain cells and tissues and are involved in the regulation of their function and that cholinergic dysfunction is related to the pathophysiology of certain diseases. They also provide clues for development of drugs with novel mechanisms of action.
Koichiro Kawashima; Takeshi Fujii
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-02-16
Journal Detail:
Title:  Journal of pharmacological sciences     Volume:  106     ISSN:  1347-8613     ISO Abbreviation:  J. Pharmacol. Sci.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167001     Medline TA:  J Pharmacol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  167-73     Citation Subset:  IM    
Department of Pharmacology, Kyoritsu College of Pharmacy, Minato-ku, Tokyo, Japan.
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MeSH Terms
Acetylcholine / metabolism*
Amnion / metabolism
Cells / metabolism
Muscle, Skeletal / metabolism
Ovary / metabolism
Placenta / metabolism
Tendons / metabolism
Urinary Bladder / metabolism
Reg. No./Substance:

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