| Basic and clinical aspects of gastrointestinal pain. | |
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MedLine Citation:
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PMID: 19155134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gastrointestinal (GI) tract is a system of organs within multicellular animals which facilitates the ingestion, digestion, and absorption of food with subsequent defecation of waste. A complex arrangement of nerves and ancillary cells contributes to the sensorimotor apparatus required to subserve such essential functions that are with the exception of the extreme upper and lower ends of the GI tract normally subconscious. However, it also has the potential to provide conscious awareness of injury. Although this function can be protective, when dysregulated, particularly on a chronic basis, the same system can lead to considerable morbidity. The anatomical and molecular basis of gastrointestinal nociception, conditions associated with chronic unexplained visceral pain, and developments in treatment are presented in this review. |
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Authors:
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Charles H Knowles; Qasim Aziz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-01-19 |
Journal Detail:
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Title: Pain Volume: 141 ISSN: 1872-6623 ISO Abbreviation: Pain Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-02 Completed Date: 2009-04-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7508686 Medline TA: Pain Country: Netherlands |
Other Details:
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Languages: eng Pagination: 191-209 Citation Subset: IM |
Affiliation:
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Neurogastroenterology Group, Centres for Academic Surgery, Barts and the London NHS Trust and the Homerton, University NHS Foundation Trust, 3rd Floor Alexandra Wing, Royal London Hospital, London E1 1BB, UK. c.h.knowles@qmul.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gastrointestinal Tract / pathology*, physiopathology* Humans Pain / pathology*, physiopathology* Visceral Afferents / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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