Document Detail


Basic and clinical aspects of gastrointestinal pain.
MedLine Citation:
PMID:  19155134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The gastrointestinal (GI) tract is a system of organs within multicellular animals which facilitates the ingestion, digestion, and absorption of food with subsequent defecation of waste. A complex arrangement of nerves and ancillary cells contributes to the sensorimotor apparatus required to subserve such essential functions that are with the exception of the extreme upper and lower ends of the GI tract normally subconscious. However, it also has the potential to provide conscious awareness of injury. Although this function can be protective, when dysregulated, particularly on a chronic basis, the same system can lead to considerable morbidity. The anatomical and molecular basis of gastrointestinal nociception, conditions associated with chronic unexplained visceral pain, and developments in treatment are presented in this review.
Authors:
Charles H Knowles; Qasim Aziz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-01-19
Journal Detail:
Title:  Pain     Volume:  141     ISSN:  1872-6623     ISO Abbreviation:  Pain     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  191-209     Citation Subset:  IM    
Affiliation:
Neurogastroenterology Group, Centres for Academic Surgery, Barts and the London NHS Trust and the Homerton, University NHS Foundation Trust, 3rd Floor Alexandra Wing, Royal London Hospital, London E1 1BB, UK. c.h.knowles@qmul.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Gastrointestinal Tract / pathology*,  physiopathology*
Humans
Pain / pathology*,  physiopathology*
Visceral Afferents / physiopathology
Grant Support
ID/Acronym/Agency:
//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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