Document Detail

Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors.
MedLine Citation:
PMID:  22048864     Owner:  NLM     Status:  MEDLINE    
This article reviews the current knowledge and experimental research about the mechanisms by which fatty acids and their derivatives control specific gene expression involved during carcinogenesis. Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism.
Andrea Comba; Yi-Hui Lin; Aldo Renato Eynard; Mirta Ana Valentich; Martín Ernesto Fernandez-Zapico; Marìa Eugenia Pasqualini
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cancer metastasis reviews     Volume:  30     ISSN:  1573-7233     ISO Abbreviation:  Cancer Metastasis Rev.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-04-02     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8605731     Medline TA:  Cancer Metastasis Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  325-42     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Fatty Acids / biosynthesis,  metabolism*,  therapeutic use
Gene Expression Regulation, Neoplastic*
Neoplasms / drug therapy,  metabolism,  pathology*
Signal Transduction*
Transcription Factors / metabolism*
Grant Support
P30 DK084567/DK/NIDDK NIH HHS; P30 DK084567-03/DK/NIDDK NIH HHS; P30 DK84567/DK/NIDDK NIH HHS; P50 CA102701/CA/NCI NIH HHS; P50 CA102701/CA/NCI NIH HHS; P50 CA102701-04/CA/NCI NIH HHS; R01 CA136526/CA/NCI NIH HHS; R01 CA136526-03/CA/NCI NIH HHS
Reg. No./Substance:
0/Fatty Acids; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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