| Baseline predictors of virological response for chronic hepatitis B patients. | |
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MedLine Citation:
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PMID: 19750575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine which baseline factors of chronic hepatitis B patients are predictive of virological response to Peginterferon alpha-2b therapy. METHODS: A total of 21 HBeAg-positive chronic hepatitis B (CHB) patients treated with Peginterferon alpha-2b were recruited. They were treated with Peginterferon alpha-2b (0.5-1.0 microg/kg per week) for 24 wk and followed up for 24 wk. Clinical and laboratory data of the patients were determined at pretreatment and at week 12, at 24 during treatment, and at week 48 during follow up. RESULTS: Ten patients achieved a virological response at the end of treatment. Their baseline serum alanine aminotransferase (ALT), thyroid-stimulating hormone (TSH), and total thyroxin (TT4) levels were significantly different from those who failed treatment. The positive predictive values (PPV) and negative predictive values (NPV) of ALT, TSH, and TT4 were 75% and 89 %, 75% and 89 %, and 75% and 75%, respectively. Moreover, combinations of the baseline ALT and TT4, ALT and TSH, TT4 and TSH levels had much higher PPV and NPV (86% and 88%, 89% and 100%, 83% and 100%, respectively). CONCLUSION: Baseline serum ALT, TSH, and TT4 levels, especially in combination, have high predictive values of virological response to Peginterferon alpha-2b in HBeAg-positive CHB patients. |
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Authors:
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Xue-Jie Wu; Yan Wang; Ji Chen; Gui-Qiang Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 15 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-14 Completed Date: 2009-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 4311-5 Citation Subset: IM |
Affiliation:
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Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiviral Agents / therapeutic use* Biological Markers / blood Female Hepatitis B e Antigens / blood Hepatitis B virus / drug effects* Hepatitis B, Chronic / drug therapy*, epidemiology, virology Humans Interferon Alfa-2b / therapeutic use* Male Polyethylene Glycols / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Biological Markers; 0/Hepatitis B e Antigens; 0/Polyethylene Glycols; 0/peginterferon alfa-2b; 99210-65-8/Interferon Alfa-2b |
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