Document Detail

Baseline predictors of virological response for chronic hepatitis B patients.
MedLine Citation:
PMID:  19750575     Owner:  NLM     Status:  MEDLINE    
AIM: To determine which baseline factors of chronic hepatitis B patients are predictive of virological response to Peginterferon alpha-2b therapy.
METHODS: A total of 21 HBeAg-positive chronic hepatitis B (CHB) patients treated with Peginterferon alpha-2b were recruited. They were treated with Peginterferon alpha-2b (0.5-1.0 microg/kg per week) for 24 wk and followed up for 24 wk. Clinical and laboratory data of the patients were determined at pretreatment and at week 12, at 24 during treatment, and at week 48 during follow up.
RESULTS: Ten patients achieved a virological response at the end of treatment. Their baseline serum alanine aminotransferase (ALT), thyroid-stimulating hormone (TSH), and total thyroxin (TT4) levels were significantly different from those who failed treatment. The positive predictive values (PPV) and negative predictive values (NPV) of ALT, TSH, and TT4 were 75% and 89 %, 75% and 89 %, and 75% and 75%, respectively. Moreover, combinations of the baseline ALT and TT4, ALT and TSH, TT4 and TSH levels had much higher PPV and NPV (86% and 88%, 89% and 100%, 83% and 100%, respectively).
CONCLUSION: Baseline serum ALT, TSH, and TT4 levels, especially in combination, have high predictive values of virological response to Peginterferon alpha-2b in HBeAg-positive CHB patients.
Xue-Jie Wu; Yan Wang; Ji Chen; Gui-Qiang Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  15     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-14     Completed Date:  2009-09-30     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  4311-5     Citation Subset:  IM    
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MeSH Terms
Antiviral Agents / therapeutic use*
Biological Markers / blood
Hepatitis B e Antigens / blood
Hepatitis B virus / drug effects*
Hepatitis B, Chronic / drug therapy*,  epidemiology,  virology
Interferon-alpha / therapeutic use*
Polyethylene Glycols / therapeutic use*
Recombinant Proteins
Reg. No./Substance:
0/Antiviral Agents; 0/Biological Markers; 0/Hepatitis B e Antigens; 0/Interferon-alpha; 0/Polyethylene Glycols; 0/Recombinant Proteins; 0/peginterferon alfa-2b; 99210-65-8/interferon alfa-2b

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