Document Detail

Baseline myocardial perfusion predicts response to cardiac resynchronization therapy: a prospective observational study.
MedLine Citation:
PMID:  18686023     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We prospectively determined whether preimplant myocardial perfusion imaging (MPI) predicts outcome with biventricular pacing (BiVP). METHODS: Single-photon emission computed tomography (SPECT) MPI, left ventricular (LV) volumes, ejection fraction (EF), 6-min hall walk (6MW) were assessed at baseline and at 4 months in 19 patients with ischemic cardiomyopathy undergoing BiVP. Clinical and hemodynamic responses were correlated with MPI. RESULTS: Lower global myocardial scar burden predicted hemodynamic response to BiVP, while higher burden was associated with poor response. Clinical improvement with BiVP occurred in 12 (63%) of the patients. Clinical BiVP responders had lower rest/stress MPI score difference. There was a close negative correlation between MPI reversibility and increased 6MW distance. CONCLUSIONS: Baseline MPI is associated with clinical and hemodynamic response to BiVP: greater myocardial scar burden is predictive of poor hemodynamic response, while higher ischemic burden is predictive of poor clinical response. There is a differential response to BiVP by clinical and hemodynamic criteria.
Michael V Orlov; Michael Maysky; Spyridon T Akrivakis; Michael R Ujhelyi; Peter Hoffmeister; Gunjan Shukla; Susan McAllister; Gregory Kotler; Ibrahim Almasry; G Muqtada Chaudhry; Charles I Haffajee
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Publication Detail:
Type:  Journal Article     Date:  2008-08-07
Journal Detail:
Title:  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     Volume:  23     ISSN:  1383-875X     ISO Abbreviation:  J Interv Card Electrophysiol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708966     Medline TA:  J Interv Card Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  IM    
Caritas St. Elizabeth's Medical Center, 736 Cambridge Street, Boston, MA, 02135, USA,
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MeSH Terms
Cardiac Pacing, Artificial*
Exercise Test
Myocardial Ischemia / physiopathology,  radionuclide imaging*,  therapy*
Prospective Studies
Quality of Life
Radiopharmaceuticals / diagnostic use
Statistics, Nonparametric
Technetium Tc 99m Sestamibi / diagnostic use
Tomography, Emission-Computed, Single-Photon*
Reg. No./Substance:
0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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