Document Detail

Baseline measures of fatty acid ethyl esters in hair of neonates born to abstaining or mild social drinking mothers.
MedLine Citation:
PMID:  16306859     Owner:  NLM     Status:  MEDLINE    
Elevated levels of fatty acid ethyl esters have been documented in the meconium of neonates born to heavily drinking mothers. Recently, accumulation of FAEE has been documented in the hair of drinking adults. To be able to use this test in the diagnosis of Fetal Alcohol Spectrum Disorder, one needs to establish baseline FAEE levels in infants born to nonalcoholic women because ethanol occurs in the baby naturally even without drinking. Scalp hair of 56 infants born to nonalcoholic women attending a well-baby clinic was obtained. Levels of FAEE were measured by GC-MS. FAEE were detected in almost all hair samples. Offspring of women admitting to mild, infrequent drinking did not differ in FAEE hair levels from infants of total abstainers. Baseline levels of FAEE in neonatal hair of nonalcoholic mothers have been established. Mild infrequent maternal drinking does not elevate these baseline levels. This may help avoid false-positive determinations when assessing infants born to problem drinking mothers.
Daniela L Caprara; Julia Klein; Gideon Koren
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  27     ISSN:  0163-4356     ISO Abbreviation:  Ther Drug Monit     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-24     Completed Date:  2006-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  811-5     Citation Subset:  IM    
Division of Clinical Pharmacology/Toxicology and Motherisk Program, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Alcohol Drinking / metabolism,  physiopathology*
Birth Weight
Body Size
Educational Status
Fatty Acids / analysis*,  standards
Gas Chromatography-Mass Spectrometry
Hair / chemistry*,  physiology
Infant, Newborn
Maternal Exposure
Pregnancy Trimesters
Reference Standards
Social Behavior
Reg. No./Substance:
0/Esters; 0/Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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