Document Detail


Baseline glutathione peroxidase activity affects prognosis after acute coronary syndromes.
MedLine Citation:
PMID:  18941641     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidative stress is associated with atherosclerosis and plaque lesions in experimental in vitro models. Few in vivo studies have examined the association between redox status and the prognosis of acute coronary syndromes.We undertook a prospective, observational study of 137 patients who had been admitted because of an acute coronary syndrome. We determined glutathione peroxidase activity (a marker of systemic antioxidant status) and recorded clinical and angiographic features and cardiovascular events (cardiovascular death, reinfarction, readmission with a new ischemic event, or need for coronary revascularization).The mean age of the patients (78% of whom were men) was 61.7 +/- 10.9 years; 76% were admitted with non-ST-segment-elevation acute coronary syndrome. Left ventricular ejection fraction was normal in 61%. In the 23.4% who experienced cardiovascular events, glutathione peroxidase activity was higher (mean, 2.38 vs 1.76 mU/mg of protein; P < 0.01). Two-year event-free survival was lower in patients whose glutathione peroxidase activity was higher than the 50th percentile (63% vs 82%; P = 0.01). Multivariate analysis showed a direct independent relationship between glutathione peroxidase activity and cardiovascular events (hazard ratio, 3.72; 95% confidence interval, 1.53-9.02; P < 0.01).We conclude that patients who experienced acute coronary syndromes and events during follow-up had higher plasma glutathione peroxidase activity, and that glutathione peroxidase activity was an independent predictor of events during follow-up.
Authors:
José Manuel García-Pinilla; Julio Gálvez; Fernando Cabrera-Bueno; Manuel Jiménez-Navarro; Juan José Gómez-Doblas; Milagros Galisteo; Desiré Camuesco; Carlos de Teresa Galván; Salvador Espinosa-Caliani; Antonio Zarzuelo; Eduardo de Teresa-Galván
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  35     ISSN:  0730-2347     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-22     Completed Date:  2009-01-09     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  262-7     Citation Subset:  IM    
Affiliation:
Servicio de Cardiología, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain. pinilla@secardiologia.es
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / mortality,  physiopathology*,  surgery
Adult
Aged
Aged, 80 and over
Coronary Angiography
Female
Glutathione Peroxidase / blood*
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Myocardial Infarction / mortality,  physiopathology,  surgery
Oxidative Stress / physiology*
Prognosis
Prospective Studies
Recurrence
Chemical
Reg. No./Substance:
EC 1.11.1.9/Glutathione Peroxidase
Comments/Corrections

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